Perioperative GFAP and Neurological Complications After Carotid Endarterectomy

Condition(s) studied

Investigational drug(s) / intervention(s)

Serum GFAP Measurement: Serum glial fibrillary acidic protein (GFAP) is measured before carotid endarterectomy and 24 hours after surgery. The measurements are collected for observational analysis and do not determine the participant's clinical care.

Study summary

This prospective, single-center observational study will evaluate whether blood levels of glial fibrillary acidic protein (GFAP), a protein associated with injury to supporting cells in the brain, are related to neurological complications after carotid endarterectomy. Adults aged 35 to 90 years undergoing elective isolated carotid endarterectomy will be enrolled. Serum GFAP will be measured before surgery and 24 hours after surgery. Investigators will record perioperative clinical information and postoperative neurological outcomes, including transient ischemic attack, stroke, delirium, and cognitive dysfunction. Approximately 90 participants are planned. The study will not assign any treatment or procedure.

Eligibility

Primary outcome measure(s)

• Number of Participants With Postoperative Neurological Complications — At hospital discharge
  Number of participants who experience at least one postoperative neurological complication after carotid endarterectomy: transient ischemic attack, stroke, delirium, or cognitive dysfunction. A participant with more than one event will be counted once in this composite outcome.

Trial sites (1)

Other trials for the same condition