Antibacterial Effects of Intracanal Medicaments in Acute Apical Abscesses

Condition(s) studied

Investigational drug(s) / intervention(s)

Calcium Hydroxide Intracanal Medicament: Calcium hydroxide-based intracanal medicament placed into the prepared root canal to 1 mm short of the working length for 7 to 10 days.

Calcium Silicate-Based Intracanal Medicament: Calcium silicate-based intracanal medicament placed into the prepared root canal to 1 mm short of the working length for 7 to 10 days.

Study summary

This randomized clinical trial compares the antibacterial effects of calcium hydroxide and a calcium silicate-based intracanal medicament in teeth with acute apical abscesses. Microbiological samples are collected before root canal preparation, after chemomechanical preparation, and after intracanal medication. Bacterial levels are measured using Real-Time PCR. The main objective is to determine which intracanal medicament provides a greater reduction in the total bacterial load after a 7- to 10-day medication period.

Eligibility

Primary outcome measure(s)

• Change in Total Bacterial Load After Intracanal Medication — From immediately after chemomechanical preparation to 7 to 10 days after intracanal medicament placement
  Total bacterial load will be quantified using universal 16S rRNA gene-based Real-Time PCR in samples collected after chemomechanical root canal preparation (S2) and after the 7- to 10-day intracanal medication period (S3). The antibacterial effect will be evaluated as the change in log10 bacterial load from S2 to S3 and compared between the two intervention groups.

Trial sites (1)

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