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Clinical Trials in Turkey / NCT07560683
Starting soon Observational

Barrier Functions oF Skin in ICU: SKIN-BAR

NCT07560683 · tracked via the Priya Life Science Turkey tracker
Sponsor
Koç University
Phase
Observational
Started
2026-07-01
Last updated
2026-05-01

Condition(s) studied

Pressure InjuriesSkin FailureSkin AbnormalitiesBiophysical Parameters of Skin

Study summary

This study aims to investigate skin barrier function in intensive care unit (ICU) patients using biosensor-based measurements. Biophysical parameters including transepidermal water loss (TEWL), skin pH, stratum corneum hydration, local skin temperature, and sebum will be assessed in anatomical regions at risk for pressure injuries. The study will examine temporal changes in these parameters, their interrelationships, and their association with pressure injury development.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Adults aged \>18 years * Admission to the intensive care unit * Initial skin assessment completed within the first 4 hours after ICU admission * Hemodynamically stable enough to undergo follow-up and repeated skin measurements * Intact skin integrity at ICU admission * Willingness to participate in the study, with informed consent provided by the participant or legally authorized representative Exclusion Criteria: * Inability to tolerate position changes * Post-cardiopulmonary resuscitation care period at enrollment * Cardiac arrest or cardiopulmonary resuscitation during follow-up * Severe edema or subcutaneous fluid accumulation * Presence of skin lesions before ICU admission * Systemic dermatologic disease directly affecting skin barrier function

Primary outcome measure(s)

  • Change in transepidermal water loss (TEWL) in pressure injury-prone anatomical regions — From ICU admission (within the first 4 hours), 24 hours, 48 hours, 96 hours, day 13.
    Transepidermal water loss (TEWL) values measured using a non-invasive biosensor device in pressure injury-prone anatomical regions, including the sacrum, right and left trochanters, right and left lateral legs, right and left scapulae, and posterior neck. TEWL will be evaluated longitudinally to determine temporal changes in skin barrier function and its association with pressure injury development.

Trial sites (1)

FacilityCityRegionStatus
Koç University Istanbul Turkey (Türkiye)

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07560683 on ClinicalTrials.gov ↗ ← All trials in Turkey