Ireland
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Enrolling by invitation Not applicable

Comparison of TAP and QL Blocks for Postoperative Analgesia in Open Inguinal Hernia Repair

NCT07527065 · tracked via the Priya Life Science Turkey tracker
Phase
Not applicable
Started
2025-09-29
Last updated
2026-04-22

Condition(s) studied

Postoperative Pain

Investigational drug(s) / intervention(s)

Transversus Abmoninis Plane BlockQuadro-Iliac Plane Block

Transversus Abmoninis Plane Block: With the patient in the supine position, the needle insertion site will be sterilized with 10% povidone-iodine. A linear ultrasound probe will be covered in a sterile manner. A 22-25G, 50-100 mm peripheral nerve block needle will be used. The ultrasound probe will be placed at the level of the umbilicus along the midaxillary line. After identifying the three abdominal muscle layers, the fascial plane between the internal oblique and transversus abdominis muscles will be visualized. The needle will be advanced using the in-plane technique (medial-to-lateral or lateral-to-medial). A total of 30 mL of 0.25% bupivacaine will be injected into the fascial plane between the relevant muscle layers.

Quadro-Iliac Plane Block: With the patient in the prone position, the needle insertion site will be sterilized with 10% povidone-iodine, and the linear ultrasound probe will be prepared in a sterile manner. The probe will be positioned to visualize the L3 spinous process at the midline. After slight lateral movement, the transverse process within the erector spinae muscle will be identified. When the probe is rotated sagittally and moved caudally, the iliac crest will be visualized. The erector spinae, quadratus lumborum, and psoas major muscles will be identified. The needle will be advanced in-plane from cranial to caudal. After hydrodissection with 2 mL of normal saline, 30 mL of 0.25% bupivacaine will be injected.

Study summary

Background Postoperative pain management after open inguinal hernia repair remains a clinical challenge despite spinal anesthesia. Ultrasound-guided fascial plane blocks, such as Transversus Abdominis Plane (TAP) block and Quadratus Lumborum Block (QLB), have been increasingly used as part of multimodal analgesia. This study aimed to compare their effects on postoperative opioid consumption.

Methods After ethics committee approval, 70 patients aged 18-65 years with ASA I-II undergoing elective unilateral inguinal hernia repair were included in this prospective, randomized study. Patients were allocated into two groups: Group Q (QLB) and Group T (TAP). Blocks were performed preoperatively under ultrasound guidance using the in-plane technique with 30 mL of 0.25% bupivacaine. Block success was defined as sensory blockade at T10-L1 dermatomes at 30 minutes.

All patients received spinal anesthesia at the L3-L4 level with 12.5 mg of 0.5% isobaric bupivacaine. Postoperatively, patient-controlled analgesia (PCA) with tramadol was administered for 24 hours. Pain scores were assessed using the Numeric Rating Scale (NRS) at PACU and at 1, 3, 6, 12, 18, and 24 hours. Opioid consumption was recorded at 0-1, 2-12, 12-24 hours, and cumulatively over 24 hours. Postoperative side effects were also evaluated.

Results Both QLB and TAP block provided effective postoperative analgesia. There were no significant differences between the groups in terms of total 24-hour opioid consumption or NRS pain scores at measured time points. However, QLB demonstrated a trend toward prolonged analgesic duration and wider dermatomal spread.

Conclusion Both TAP and QLB are effective adjuncts to spinal anesthesia for postoperative analgesia in unilateral inguinal hernia repair. While QLB may offer broader and longer-lasting analgesia, its superiority over TAP block in reducing opioid consumption was not statistically significant.

Eligibility

Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria: * Will undergo Open Inguinal Hernia Repair * The American Society of Anesthesiologists (ASA) physical classification is 1-2. * The volunteer has read and accepted the consent form * Body mass index (BMI) \<35 Exclusion Criteria: * Body mass index (BMI) \>35 kg/m² * American Society of Anesthesiologists (ASA) physical status III-V * Inability to assess pain using the Numeric Rating Scale (NRS) * Known allergy to the local anesthetic or the planned analgesic agent * Self-reported pregnancy or breastfeeding * Age \<18 or \>65 years * Uncontrolled anxiety * Alcohol or substance abuse * Neuromuscular disease or peripheral neuropathy * Use of high-dose opioid medication within three days prior to surgery widespread chronic pain * Diabetes mellitus * Hepatic or renal insufficiency * Coagulation disorders * Current use of anticoagulant therapy * Infection at the site of peripheral block needle insertion * Ireducible, incarcerated, strangulated, or recurrent inguinal hernia * Inability to communicate in Turkish * Technical problems during the use of the patient-controlled analgesia (PCA) device * NRS score persistently above 7 for four consecutive hours despite the planned multimodal analgesia regimen * Inability to understand or use the Verbal Rating Scale for pain assessment and the Quality of Recovery-15 (QoR-15) questionnaire * Termination of surgery before completion for any reason.

Primary outcome measure(s)

  • Postoperative Pain Examination with Numeric Rating Scale — 24 hours
    Determination of patients' post-operative pain level. The Numeric Rating Scale (NRS), a method that converts the patient's pain perception into a numerical form, will be used to assess postoperative pain. NRS has a numerical scale ranging from 0 to 10. The patient will rate the intensity of pain on a scale from 0, indicating no pain, to 10, representing the worst imaginable pain (NRS 0=no pain, 4=mild to moderate pain, 6-8=severe pain, and \>8=intolerable pain). The NRS score will be evaluated both at rest and during active movement situations (such as transitioning from a lying to a sitting position).

Trial sites (1)

FacilityCityRegionStatus
Hitit University Erol Olcok Training and Research Hospital, Çorum Turkey (Türkiye)
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07527065 on ClinicalTrials.gov ↗ ← All trials in Turkey