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Clinical Trials in Turkey / NCT07521566
Active, not recruiting Not applicable

Histological and Clinical Evaluation of De-epithelialized Connective Tissue Grafts Obtained by Different Methods

NCT07521566 · tracked via the Priya Life Science Turkey tracker
Sponsor
Dokuz Eylul University
Phase
Not applicable
Started
2025-09-19
Last updated
2026-04-13

Condition(s) studied

Gingival RecessionsGingival Recession, Mucogingival Surgery

Investigational drug(s) / intervention(s)

Extraoral de-epithelialization GroupRadiofrequency De-epithelialization

Extraoral de-epithelialization Group: Extraoral de-epithelialization of connective tissue grafts using a scalpel prior to graft placement.

Radiofrequency De-epithelialization: Intraoral de-epithelialization of connective tissue grafts using a radiofrequency device prior to graft placement.

Study summary

This randomized controlled clinical study aimed to evaluate the effectiveness of two different de-epithelialization techniques-extraoral scalpel and intraoral radiofrequency (RF)-used in the preparation of de-epithelialized connective tissue grafts (De-CTG) for the treatment of gingival recession. A total of 48 patients were randomly assigned into two groups, and all grafts were applied in combination with coronally advanced flap (CAF) surgery. Clinical and histological outcomes, including epithelial remnants, root coverage, keratinized tissue gain, surgical duration, and postoperative patient comfort, were assessed. The study seeks to identify a reliable, operator-independent method that minimizes epithelial remnants and improves clinical outcomes and patient experience.

Eligibility

Sex
ALL
Min age
18 Years
Max age
80 Years
Healthy volunteers
Accepted
Inclusion Criteria: * Voluntary individuals aged between 18 and 80 years * Systemically healthy * Non-smokers * Patients diagnosed with periodontal health following Phase I therapy, with reduced periodontium both clinically and radiographically * Presence of Cairo RT I and RT II gingival recession defects involving maxillary and mandibular anterior and premolar teeth * Presence of at least 1 mm of keratinized gingiva * Individuals not using any medications that may affect periodontal tissue health or wound healing * Absence of any pathology in the palatal mucosa that may interfere with the surgical procedure for connective tissue harvesting Exclusion Criteria: * Teeth with caries, non-carious cervical lesions, or restorations in the gingival recession area * Teeth with endodontic pathology * Pregnant or lactating women * Patients with cardiac pacemakers * Teeth where the cementoenamel junction cannot be clearly identified * Individuals for whom the use of a radiofrequency device may pose a risk * Use of antibiotics or immunosuppressive medications within the last 3 months

Primary outcome measure(s)

  • Presence of Epithelial Remnants — At the time of surgery
    Histological evaluation of harvested grafts to determine the presence or absence of epithelial remnants after de-epithelialization using scalpel or radiofrequency methods.
  • Complete Root Coverage — 3-6 months
    The percentage of gingival recession defects achieving complete root coverage following treatment with de-epithelialized connective tissue grafts prepared using either scalpel or radiofrequency techniques in combination with coronally advanced flap surgery.

Trial sites (1)

FacilityCityRegionStatus
Dokuz Eylul University Izmir Turkey (Türkiye)

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07521566 on ClinicalTrials.gov ↗ ← All trials in Turkey