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Clinical Trials in Turkey / NCT07520812
Starting soon Not applicable

Impact of Exercise Training on Serum Neurofilament Light Chain (NfL), Brain Volumetry, and Functional Outcomes in Multiple Sclerosis

NCT07520812 · tracked via the Priya Life Science Turkey tracker
Sponsor
Firat University
Phase
Not applicable
Started
2026-04-15
Last updated
2026-04-09

Condition(s) studied

Multiple SclerosisExerciseNeurofilament Light Chain

Investigational drug(s) / intervention(s)

Exercise

Exercise: According to current clinical guidelines for multiple sclerosis patients, the progressive resistance training (PRT) protocol will be implemented as follows: a 12-week intervention consisting of three supervised 60-90 minute sessions per week at 60-80% of one-repetition maximum intensity. All training sessions will be conducted under the direct supervision of a certified physiotherapist to ensure proper technique adherence and safety throughout the intervention period

Study summary

This single-blind, randomized controlled trial will employ a two-arm parallel design (exercise group vs. control group) with a 12-week intervention period. Randomization will be implemented using SPSS 25.0 (IBM Corporation, Armonk, NY, USA) to ensure balanced group allocation. All outcome measures will be assessed at baseline and post-intervention.

Eligibility

Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria: * Clinically confirmed relapsing-remitting multiple sclerosis (RRMS) diagnosis according to revised McDonald criteria (2017) * Mild-to-moderate disability (EDSS score 1.0-5.5) * No corticosteroid treatment within the previous 3 months Exclusion Criteria: * Acute MS relapse within 90 days prior to enrollment * Regular participation in structured exercise programs (\>3 hours/week) * Comorbid conditions that may limit exercise participation, including; significant orthopedic impairments, unstable cardiopulmonary conditions and other systemic disorders affecting physical activity * Standard MRI contraindications (metallic implants, claustrophobia, etc.) * Concurrent neurological disorders (other than MS) * Initiation or modification of disease-modifying therapy within 6 months * Severe spasticity (Modified Ashworth Scale ≥3 in any major muscle group)

Primary outcome measure(s)

  • MRI Acquisition and Volumetric Analysis — 12 weeks
    Volumetric brain analysis will be conducted using VolBrain, an open-access automated segmentation platform for brain MRI.
  • Serum Neurofilament Light Chain (NfL) measurement — 12 Weeks
    All patients will be asked to provide blood samples in the morning following their overnight (12 h) fast before and after the study. The unit ng/ml will be used for serum Neurofilament Light Chain.

Trial sites (1)

FacilityCityRegionStatus
Fırat University Elâzığ Turkey (Türkiye)

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Other trials for the same condition

Acute Effects of Oculomotor Exercises on Posturography and Gait Analysis Parameters in Regular Exercisers Active, not recruiting
Fatigue and Mental Well-Being in MS Patients(Multiple Sclerosis) Recruiting
Effect of Multimodal Exercise Training in Patients With Multiple Sclerosis Recruiting
Development of a Chatbot-supported Personalized Exercise Program for Older Adults and Evaluation of Its Effects on Cognitive Functions Starting soon
Cone Evasion Walk Test in Multiple Sclerosis Starting soon
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07520812 on ClinicalTrials.gov ↗ ← All trials in Turkey