Effect of Trendelenburg Position on Patient State Index

Condition(s) studied

Study summary

The goal of this observational study is to evaluate whether the Trendelenburg position affects electroencephalography-based depth of anesthesia monitoring and cerebral oxygenation during general anesthesia.

The main questions it aims to answer are:

* Does the Trendelenburg position cause a change in the Patient State Index (PSI), an Electroensephalography (EEG)-derived indicator of anesthetic depth?
* Are changes in PSI associated with changes in frontal cerebral oxygen saturation (rSO₂) and hemodynamic parameters?

The study will include adult female patients undergoing elective laparoscopic gynecologic surgery under general anesthesia.

Participants will receive standard anesthesia and routine intraoperative monitoring. In addition to standard monitoring, Patient State Index (PSI) and frontal cerebral oxygen saturation (rSO₂) will be recorded using non-invasive sensors. No additional intervention will be performed for research purposes.

Physiological parameters including PSI, cerebral oxygen saturation, mean arterial pressure, heart rate, oxygen saturation, and end-tidal carbon dioxide will be recorded at predefined intraoperative time points before and after the Trendelenburg position.

The study aims to determine whether position-related physiological changes influence EEG-based anesthesia depth indices and to improve the interpretation of intraoperative brain monitoring.

Eligibility

Primary outcome measure(s)

• Change in Patient State Index (ΔPSI) After Trendelenburg Position — From Post-intubation (Supine) to Trendelenburg Positioning
  The primary outcome is the change in Patient State Index (PSI), an Electroensephalography(EEG)-derived indicator of anesthetic depth, between the supine position after tracheal intubation and the early Trendelenburg position following pneumoperitoneum. PSI values will be recorded using the Masimo SedLine monitoring system. The analysis will evaluate whether Trendelenburg positioning is associated with a significant change in PSI independent of anesthetic drug concentration.

Trial sites (1)

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