Tranexamic Acid Dose and Remifentanil Titration in Septorhinoplasty

Condition(s) studied

Investigational drug(s) / intervention(s)

NASA Task Load Index (NASA-TLX): Postoperative assessment of anesthesiologist workload using the NASA Task Load Index (raw scoring method), completed immediately after each operation by the attending anesthesiologist.

Study summary

This prospective observational cohort study aims to investigate whether the weight-based equivalent (mg/kg) of a fixed 1 g dose of tranexamic acid administered during septorhinoplasty is associated with intraoperative remifentanil titration frequency and perceived anesthesiologist workload. Although tranexamic acid is routinely given as a fixed dose, its mg/kg equivalent varies according to patient weight and may influence hemodynamic management during controlled hypotension. The primary outcome is the total number of remifentanil infusion rate adjustments during surgery. Secondary outcomes include total remifentanil consumption and postoperative anesthesiologist workload assessed using the NASA Task Load Index (NASA-TLX).

Eligibility

Primary outcome measure(s)

• Intraoperative Remifentanil Titration Frequency — Intraoperative period (from induction of anesthesia to end of surgery).
  Total number of intraoperative remifentanil infusion rate adjustments (each increase or decrease counted as one intervention) recorded during septorhinoplasty.

Trial sites (1)

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