Predictors of Trifecta Achievement After HoLEP

Condition(s) studied

Investigational drug(s) / intervention(s)

Transurethral Holmium Laser Enuclation of the Prostate: HoLEP, En-bloc or tri-lobar technique.

Study summary

Holmium laser enucleation of the prostate (HoLEP) is a surgical treatment option for men experiencing bothersome lower urinary tract symptoms due to an enlarged prostate. Researchers predict that specific participant or operator-dependent conditions before or during HoLEP may influence the trifecta outcome, based on similar studies. Therefore, the aim of this study is to understand what these conditions are. Trifecta success indicates a high-quality surgery based on three essential criteria: the treatment's effectiveness, ease of recovery, and the absence of serious side effects. In this study, trifecta is defined as relief from bothersome symptoms validated by international symptom score questionnaires, no urinary incontinence, and no serious events occurring within three months after HoLEP.

Eligibility

Primary outcome measure(s)

• Trifecta achievement three months after HoLEP — From enrollment to the three months after the intervention for each participant.
  Achievement of all three of the following criteria, three months after HoLEP: 1. At least a 30% reduction in International Prostate Symptom Score (IPSS) 2. Absence of major complications (no Clavien-Dindo grade \> II), 3. No urinary incontinence

Trial sites (1)

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