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Clinical Trials in Turkey / NCT07394738
Active, not recruiting Not applicable

Using Different Biomaterials to Preserve Bone After Tooth Extraction

NCT07394738 · tracked via the Priya Life Science Turkey tracker
Sponsor
Inonu University
Phase
Not applicable
Started
2025-04-09
Last updated
2026-03-27

Condition(s) studied

Alveolar Ridge PreservationBone RegenerationTooth ExtractionDental Implants

Investigational drug(s) / intervention(s)

AllograftAutogenous Dentin GraftHyaluronic Acid Gel

Allograft: Following tooth extraction, the socket is filled with particulate freeze-dried allograft. The material is placed in a single session immediately after extraction to support socket preservation. Healing is monitored clinically at scheduled follow-up visits.

Autogenous Dentin Graft: After tooth extraction, autogenous dentin is processed into particulate graft form and placed into the socket in the same session. The graft is used for socket preservation, and healing is assessed clinically during planned follow-up visits.

Hyaluronic Acid Gel: A hyaluronic acid gel is applied as an adjunct biomaterial in combination with dentin graft material during socket preservation. Tissue response is evaluated at scheduled follow-up visits.

Study summary

This clinical study aims to evaluate the effectiveness of different biomaterials in alveolar socket preservation following tooth extraction. Participants will be allocated into three groups: (1) dentin graft, (2) dentin graft combined with hyaluronic acid, (3) allograft and (4) natural healing without any grafting material (control group). At 4 months post-extraction, dental implants will be placed, and bone biopsies will be obtained during the procedure. These biopsy samples will be subjected to histological analysis to assess new bone formation and graft integration. The study will contribute to the understanding of biomaterial performance in socket preservation prior to implant placement.

Eligibility

Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria Adults aged 18 years or older Indicated for tooth extraction in the anterior or premolar region of the maxilla or mandible Planned socket preservation and subsequent dental implant placement at the extraction site Adequate bone volume permitting atraumatic extraction Good oral hygiene and periodontal status compatible with socket preservation Willing and able to attend scheduled follow-up visits and undergo biopsy collection prior to implant placement Able to provide written informed consent Exclusion Criteria Systemic conditions known to impair bone or soft tissue healing (e.g., uncontrolled diabetes, immunosuppression, osteoporosis) Current use of medications affecting bone metabolism (e.g., bisphosphonates, corticosteroids, anti-resorptives) Active periodontal or periapical infection at the extraction site History of head and neck radiotherapy Smoking or tobacco use within the past 6 months Pregnancy or breastfeeding Known allergy or contraindication to grafting procedures or study-related materials Inability or unwillingness to comply with follow-up visits or biopsy procedures

Primary outcome measure(s)

  • Percentage of new bone formation in the extraction socket at 4 months — 4 months after tooth extraction
    Histomorphometric analysis will be performed on biopsies harvested from the preserved sockets. The percentage of newly formed mineralized bone will be calculated as the ratio of new bone area to the total tissue area within the region of interest. Higher values indicate more favorable hard tissue regeneration in the socket preservation site.

Trial sites (1)

FacilityCityRegionStatus
Inonu University Faculty of Dentistry Malatya Battalgazi-Malatya

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07394738 on ClinicalTrials.gov ↗ ← All trials in Turkey