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Comparison of Serratus Plane Block and Rhomboid Intercostal Plane Block for Postoperative Analgesia in Breast Reduction Surgery

NCT07229092 · tracked via the Priya Life Science Turkey tracker
Sponsor
Konul Karaja
Phase
Not applicable
Started
2025-02-02
Last updated
2026-04-30

Condition(s) studied

Postoperative Analgesia in Breast Reduction SurgeryPostoperative PainPostoperative Pain Breast ReductionPain, Postoperative

Investigational drug(s) / intervention(s)

Serratus Anterior Plane Block (SAPB)Rhomboid Intercostal Plane Block (RIPB)No Regional Block (Control)

Serratus Anterior Plane Block (SAPB): "Ultrasound-guided serratus anterior plane block performed preoperatively while patients are awake. A total of 30 mL of local anesthetic solution (5 mL saline, 5 mL of 2% lidocaine, 20 mL of 0.25% bupivacaine) will be used. The total volume will be divided equally between both breasts (15 mL per side), with one injection point on each side at the midaxillary line

Rhomboid Intercostal Plane Block (RIPB): Ultrasound-guided rhomboid intercostal plane block (RIPB) performed preoperatively while patients are awake, using a total of 30 mL local anesthetic solution (5 mL normal saline, 5 mL of 2% lidocaine, and 20 mL of 0.25% bupivacaine). The total volume will be divided equally between both breasts (15 mL per side), with one injection point on each side between the rhomboid major muscle and the intercostal muscles at the medial border of the scapula around the 5th intercostal level.

No Regional Block (Control): Participants in this group will not receive any regional block. Standard general anesthesia and multimodal postoperative analgesia will be provided according to institutional protocol.

Study summary

This prospective, randomized clinical study aims to compare the analgesic efficacy of serratus plane block (SPB) and rhomboid intercostal plane block (RIPB) for postoperative analgesia in patients undergoing elective bilateral breast reduction surgery under general anesthesia. All patients will receive standardized general anesthesia. Before induction of anesthesia, while patients are awake, Group SPB will receive an ultrasound-guided serratus anterior plane block and Group RIPB will receive an ultrasound-guided rhomboid intercostal plane block. Postoperative analgesia will be maintained with intravenous patient-controlled analgesia (PCA) with opioids. Primary outcomes include postoperative pain scores and opioid consumption at 1, 6, 12, and 24 hours. Secondary outcomes include time to first analgesic demand, patient satisfaction, and block-related complications.

Eligibility

Sex
FEMALE
Min age
18 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria: * Female patients aged 18-65 years American Society of Anesthesiologists (ASA) physical status I-II Scheduled for elective bilateral breast reduction surgery under general anesthesia Willing and able to provide written informed consent Exclusion Criteria: * Allergy or contraindication to local anesthetics (bupivacaine) Coagulopathy or anticoagulant medication use Infection at or near the injection site History of chronic opioid use or psychiatric/neurological disorders affecting pain perception Body mass index (BMI) \> 35 kg/m² Refusal to participate in the study

Primary outcome measure(s)

  • Total Tramadol Consumption Within the First 24 Hours After Surgery — 24 hours after surgery
    Total opioid consumption will be recorded using intravenous patient-controlled analgesia (PCA) during the first 24 hours after surgery. The cumulative tramadol dose (mg) administered via PCA will be calculated based on the number of patient-controlled bolus doses.

Trial sites (1)

FacilityCityRegionStatus
Aydın Adnan Menderes University Hospital, Department of Anesthesiology and Reanimation Aydin Aydın
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07229092 on ClinicalTrials.gov ↗ ← All trials in Turkey