Ireland
--:--IST
Recruiting Not applicable

Evaluation of the Effect of Tea Tree and Chlorhexidine Mouthwashes on Healing After Third Molar Extraction

NCT07180498 · tracked via the Priya Life Science Turkey tracker
Phase
Not applicable
Started
2025-04-15
Last updated
2025-09-18

Condition(s) studied

Postoperative PainPostoperative ComplicationsTrismusPeriodontal Health

Investigational drug(s) / intervention(s)

Chlorhexidine Gluconate 0.12% Mouthwash →Tea Tree Oil mouthwash

Chlorhexidine Gluconate 0.12% Mouthwash: Participants will be prescribed to gargle with chlorhexidine, which is the routine recommendation after brushing their teeth 3 times a day for 7 days after the impacted tooth extraction.

Tea Tree Oil mouthwash: Participants will be prescribed to gargle with tea tree oil-containing water after brushing their teeth three times a day for 7 days following the extraction of an impacted tooth.

Study summary

The purpose of this clinical study is to compare the effects of mouthwashes containing Chlorhexidine and tea tree oil on edema, pain, and trismus after the extraction of impacted third molars. Additionally, the effects on periodontal health will be examined by comparing the gum healing processes of patients using both mouthwashes.The main questions it aims to answer are:

1. Tea tree oil, said to have anti-inflammatory and antibacterial effects, could be an alternative to chlorhexidine in reducing postoperative complications after impacted tooth extraction.
2. Does tea tree oil, which has antimicrobial effects, have as positive an impact on periodontal health as chlorhexidine?Researchers will compare tea tree oil to chlorhexidine (routinely prescribed after the extraction of an impacted wisdom tooth) to see if tea tree oil works to decrease postoperative complications.

Participants will:

For 7 days after the operation, they will gargle with chlorhexidine mouthwash or mouthwash containing tea tree oil 3 times a day. They will come to the clinic for check-ups and measurements on the 2nd and 7th days after the operation. They will record their pain levels and the number of painkillers they take daily.

Eligibility

Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
Accepted
Inclusion Criteria: * Individuals undergoing extraction of Class 2, Class B mandibular third molars impacted in the lower jaw (Pell \& Gregory). * Individuals aged 18-65. * Individuals must be in stable general health (e.g., free of serious cardiovascular or kidney disease). * Individuals willing to use tea tree extract or other treatments. Exclusion Criteria: * Individuals with a known allergy or hypersensitivity to tea tree extract. * Individuals with serious illnesses such as heart failure or kidney disease. Patients with bleeding disorders. * Individuals during pregnancy and breastfeeding. * Individuals taking medications that may interact with tea tree extract (e.g., blood thinners or antihypertensives) * Individuals previously treated for edema. * Individuals with chronic edema.

Primary outcome measure(s)

  • pain VAS measurement — preoperative, postoperative day 2, post operative day 7
    The patient will be given a chart with a 7-day VAS scale for pain control after tooth extraction. They will be asked to record their pain daily on a scale of 0 (no pain) to 10 (the worst imaginable pain) for 7 days, and to note how many painkillers they used.
  • amount of mouth opening — preoperative, postoperative day 2, post operative day 7
    Restriction in mouth opening for 7 days after impacted tooth extraction surgery
  • distance from the angulus to the labial commissure, external eye angle, tragus, pogonion, and nasal line — preoperative, postoperative day 2, post operative day 7
    The amount of facial swelling during the 7 days following impacted tooth extraction surgery

Trial sites (1)

FacilityCityRegionStatus
Harran University, Faculty of Dentistry Sanliurfa Turkey (Türkiye) Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07180498 on ClinicalTrials.gov ↗ ← All trials in Turkey