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Clinical Trials in Turkey / NCT07173699
Active, not recruiting Not applicable

Evaluation of the Effect of Salivary Melatonin Levels on Postoperative Pain and Sleep Quality Following Endodontic Treatments Performed at Different Days and Times

NCT07173699 · tracked via the Priya Life Science Turkey tracker
Sponsor
Ataturk University
Phase
Not applicable
Started
2025-09-01
Last updated
2025-09-15

Condition(s) studied

Postoperative Pain After Endodontic Treatment

Investigational drug(s) / intervention(s)

root canal treatment

root canal treatment: Standardized root canal treatment performed on asymptomatic mandibular molars. Procedures include local anesthesia, rubber dam isolation, access cavity preparation, cleaning and shaping with rotary instruments, irrigation with NaOCl and EDTA, and obturation using a standardized protocol. Saliva samples are collected prior to treatment for melatonin analysis. Postoperative pain and sleep quality are assessed using validated questionnaires.

Study summary

This clinical study aims to evaluate the effect of salivary melatonin levels on postoperative pain and sleep quality in patients undergoing root canal treatment at different times of the day. Each participant will receive endodontic treatment on two asymptomatic mandibular molars, one in the morning and the other in the afternoon. Pain intensity and sleep quality will be assessed using standard questionnaires, and salivary melatonin levels will be analyzed.

Eligibility

Sex
ALL
Min age
25 Years
Max age
45 Years
Healthy volunteers
No
Inclusion Criteria: Patients aged 25-45 years Patients with two asymptomatic, devital mandibular molars in the same arch No radiographic evidence of periapical lesions or pathological formations in the teeth Patients without systemic diseases (ASA I) Patients who have not used antibiotics, analgesics, or melatonin-containing medications within the last week Patients who have signed the informed consent form Exclusion Criteria: Patients with a diagnosis of sleep disorder or those regularly using sleep medications/sedatives Patients with systemic diseases (e.g., hypertension, diabetes, endocrine disorders, etc.) Patients receiving psychiatric treatment Pregnant or breastfeeding patients Patients unable to cooperate during the treatment process Patients with restorative or periodontal complications in their teeth Patients working in a shift system

Primary outcome measure(s)

  • Postoperative pain intensity — Within 7 days after each root canal treatment session
    Pain intensity will be assessed using a 10-cm Visual Analogue Scale (VAS), where 0 represents "no pain" and 10 represents "worst pain imaginable." Participants will record their pain levels following root canal treatment sessions performed in the morning and afternoon.

Trial sites (1)

FacilityCityRegionStatus
Atatürk University Faculty of Dentistry, Department of Endodontics Erzurum Turkey (Türkiye)

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Other trials for the same condition

EFFECT OF NITI SYSTEMS AND XP-ENDO FINISHER ON POSTOPERATIVE PAIN Recruiting
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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07173699 on ClinicalTrials.gov ↗ ← All trials in Turkey