Ireland
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Recruiting Observational

Wash-in Period in Patients Undergoing Low Flow Anesthesia

NCT06967948 · tracked via the Priya Life Science Turkey tracker
Sponsor
Serkan Uckun
Phase
Observational
Started
2025-04-10
Last updated
2025-05-16

Condition(s) studied

Inhalation Anesthesia

Study summary

Volunteers above the age of 18 and below the age of 60 who agreed to participate in the study were not exposed to any interventional intervention other than those routinely applied to the patient during and after the administration of the clinical standard anesthesia protocol. The value indicating the brain's response to hypnotic substances, the vapor concentration in the lung alveoli and the minimum amount of anesthesia gas used will be recorded at certain times. The aim of the researchers in the study was to observe the effect of two different fresh gas flow rates on the amount and cost of waste gas released into the atmosphere.

Eligibility

Sex
ALL
Min age
18 Years
Max age
60 Years
Healthy volunteers
No
Inclusion Criteria: * ASA I-II risk group patients Duration of surgery between 2 hours and 4 hours, cases with general anesthesia Exclusion Criteria: * Patient refusal to participate in the study * Under 18 years old BMI\>40 * Patients receiving invasive mechanical ventilator support in the last 1 month * Patients who have received chemotherapy or radiotherapy in the last 2 months * Those with severe lung disease (COPD, asthma, pulmonary infection, bronchiectasis, previous need for non-invasive mechanical ventilation, oxygen therapy or steroid therapy for acute attack) * Known severe pulmonary hypertension * Smoke poisoning (carbon monoxide, cyanide poisoning) * Alcohol or acetone poisoning * Malignant hyperthermia * Intracranial tumor * Hemodynamic instability * Shock * Neuromuscular disease * Pathologies causing increased intracranial and intraocular pressure * Those with severe cardiac arrhythmias Those with -EF\<30 * Severe peripheral arterial disease * Patients with liver and kidney dysfunction

Primary outcome measure(s)

  • Demographic data — preoperative
    Demographic data such as age (years), height (cm), weight (kg) and gender (male/female) of the volunteer patients will be analyzed to see if they are similar for both study groups.
  • Duration of surgery — During the period of operation (2-4 hours)
    It will be examined whether the duration of surgery (minutes) is similar for volunteer patients
  • Duration of anesthesia — During the period of operation (2-4 hours)
    It will be examined whether the duration of anesthesia (minutes) is similar for volunteer patients
  • Heart rate — During the period of operation (2-4 hours)
    We will examine whether there is a difference in heart rate (beats/minute) values recorded at 5-minute intervals in the first half hour and at 15-minute intervals thereafter in volunteer patients
  • Systolic blood pressure — During the period of operation (2-4 hours)
    The volunteer patients will be examined for differences in systolic blood pressure (mmHg) values recorded at 5-minute intervals in the first half hour and at 15-minute intervals thereafter
  • Diastolic blood pressure — During the period of operation (2-4 hours)
    The volunteer patients will be examined for differences in diastolic blood pressure (mmHg) values recorded at 5-minute intervals in the first half hour and at 15-minute intervals thereafter
  • Mean blood pressure — During the period of operation (2-4 hours)
    The volunteer patients will be examined for differences in mean blood pressure (mmHg) values recorded at 5-minute intervals in the first half hour and at 15-minute intervals thereafter
  • Oxygen saturation — During the period of operation (2-4 hours)
    We will examine whether there is a difference between the oxygen saturation (%) values measured at 5-minute intervals in the first half hour and then at 15-minute intervals in volunteer patients.
  • Total inhaled gas consumption — During the period of operation (2-4 hours)
    Total inhaled gas consumption (milliliter) at the end of anesthesia will be examined whether it is similar for volunteer patients.
  • Minimum alveolar concentration (MAC) — During the period of operation (2-4 hours)
    Minimum alveolar concentration (MAC) values are recorded at 1-minute intervals in the first 10 minutes at the onset of anesthesia, at 5-minute intervals between 10 minutes and half an hour, and at 15-minute intervals after half an hour and will be examined for differences between volunteers.
  • Bispectral index (BIS) — During the period of operation (2-4 hours)
    Bispectral index (BIS) values are recorded at 1-minute intervals in the first 10 minutes at the onset of anesthesia, at 5-minute intervals between 10 minutes and half an hour, and at 15-minute intervals after half an hour and will be examined for differences between volunteers.

Trial sites (3)

FacilityCityRegionStatus
Balıkesir University Health Practice and Research Hospital Operating Room Balıkesir Turkey (Türkiye) Recruiting
Balıkesir University Health Practice and Research Hospital Balıkesir Turkey (Türkiye) Recruiting
Balıkesir University Health Practice and Research Hospital Balıkesir Turkey (Türkiye) Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06967948 on ClinicalTrials.gov ↗ ← All trials in Turkey