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Clinical Trials in Turkey / NCT06660095
Enrolling by invitation Observational

Intraoperative "p50" Measurement in Liver Transplant Surgeries

NCT06660095 · tracked via the Priya Life Science Turkey tracker
Sponsor
Inonu University
Phase
Observational
Started
2024-10-22
Last updated
2024-10-26

Condition(s) studied

Liver Transplant; Complications

Study summary

The aim of this study is to compare the p50 value in routine blood gas measurements taken during liver transplant surgery follow-up with other follow-up parameters and clinical findings on the monitors, and to investigate whether there is a predictive parameter that can predict the rapidly changing clinical findings of the patients.

Eligibility

Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria: * Liver transplant recipients who will undergo Elective Liver Transplant surgery at İnönü University Faculty of Medicine Liver Transplant Institute, ASA (American Society of Anesthesiology) score III-IV, patients between the ages of 18-65 Exclusion Criteria: * Patients with fulminant liver failure, * hepatic encephalopathy, * hepatorenal, * hepatopulmonary syndrome, * uncontrolled diabetes mellitus, * cardiovascular, pulmonary disease, * sepsis * and patients who refuse consent in the informed consent form will be excluded from the study.

Primary outcome measure(s)

  • p50 changes during liver transplant surgery — T0: at the end of the dissection before clamps T1: 5 min. before reperfusion (anhepatic) T2: 30 min. after reperfusion of the liver graft (neohepatic) T3: after hepatic artery reperfusion T4: End of the operation
    P50 is the partial pressure of oxygen required to achieve 50% haemoglobin saturation. The normal p50 value is 24-28 mmHg. The oxygen-hemoglobin dissociation curve represents the affinity of hemoglobin for oxygen. The p50 value represents a mid-point in this curve, and gives us information regarding that affinity. Determining the clinical value, if any, of the changes in p50 values taken at different stages of liver transplantation surgery may be useful in the follow-up of these patients in the future and may help in making intraoperative decisions.

Trial sites (1)

FacilityCityRegionStatus
İnönü Üniversitesi Merkez Kampüsü (Elazığ Yolu 15.km) Battalgazi Malatya Turkey (Türkiye)

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Other trials for the same condition

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06660095 on ClinicalTrials.gov ↗ ← All trials in Turkey