Effects of Resistance Training on Recovery During Hematopoietic Stem Cell Transplantation

NCT07872813 · tracked via the Priya Life Science Taiwan tracker

Sponsor

Taipei Veterans General Hospital, Taiwan

Phase

Not applicable

Started

2026-10-12

Last updated

2026-10-14

Condition(s) studied

Hematologic MalignanciesHematopoietic Stem Cell TransplantationResistance TrainingNeutropeniaAcute Graft-versus-Host DiseaseCancer-related FatigueMuscle Strength

Investigational drug(s) / intervention(s)

8-week Elastic Band Resistance Training Program

8-week Elastic Band Resistance Training Program: Participants will perform a 45-minute elastic band resistance training session 3 times per week, starting 4 weeks before the hematopoietic stem cell transplantation (HSCT) and continuing until 4 weeks after the transplant (total of 8 weeks).

Study summary

This study investigates whether a resistance training program can help patients recovering from hematopoietic stem cell transplantation (HSCT) for hematologic malignancies.

HSCT is a vital treatment, but it comes with a high risk of severe complications. These include opportunistic infections caused by low white blood cell counts (neutropenia) and acute graft-versus-host disease (aGVHD), where donor cells attack the patient's body. Additionally, more than half of patients suffered from severe cancer-related fatigue during or after transplantation, which significantly lowers their quality of life. Currently, treatments for these complications rely almost entirely on medication.

The purpose of this study is to see if an 8-week elastic band resistance training program can speed up blood cell recovery, reduce the severity of aGVHD, shorten hospital stays, and alleviate cancer-related fatigue.

A total of 86 patients preparing for HSCT at Taipei Veterans General Hospital will be randomly assigned to one of two groups:

1. The Resistance Training Group (43 patients): Participants will perform 45-minute elastic band exercises three times a week, starting four weeks before their transplant and continuing until four weeks after.
2. The Control Group (43 patients): Participants will receive standard routine care.

The study will compare the two groups by measuring how many days it takes for white blood cells to recover, the occurrence and severity of aGVHD, muscle strength (hand grip and lower limbs), fatigue levels, and the total length of hospital stays.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Patients aged 18 years and older. * Patients must be conscious. * Able to communicate in Mandarin or Taiwanese, or possess reading and writing literacy. * Diagnosed with hematological malignancies, including Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL), Hodgkin lymphoma, Non-Hodgkin lymphoma, Multiple myeloma, or Myelodysplastic Syndromes (MDS). * Scheduled to undergo hematopoietic stem cell transplantation (HSCT), including autologous and allogeneic transplantation. * Assessed by the individual subject's attending physician as eligible to participate in resistance exercise training. * ECOG performance status ≤ 2. Exclusion Criteria: * Absolute contraindications to exercise, including cardiac insufficiency (NYHA Class III/IV or unexplained arrhythmia, aortic dissection, and severe aortic stenosis), uncontrolled hypertension (resting systolic blood pressure \> 200 mmHg or diastolic blood pressure \> 110 mmHg), and severe musculoskeletal injury. * Cancellation of hematopoietic stem cell transplantation (HSCT) due to clinical deterioration or medical instability.

Primary outcome measure(s)

Score on the Brief Fatigue Inventory - Taiwan Version (BFI-T) for Cancer-Related Fatigue — From enrollment to the end of treatment at 8 weeks
The Brief Fatigue Inventory - Taiwan Version (BFI-T) is a 9-item self-report questionnaire used to assess fatigue severity and its impact on daily functioning. Each item is rated on a 0 to 10 numerical rating scale. The global score is calculated as the mean of the 9 items, ranging from 0 to 10. Higher scores indicate greater fatigue severity and greater fatigue interference with daily life.

Trial sites (1)

Facility	City	Region	Status
Taipei Veterans General Hospital	Taipei	Taiwan

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07872813 on ClinicalTrials.gov ↗ ← All trials in Taiwan