Nutritional Effects in Cardiovascular Surgery

NCT07497932 · tracked via the Priya Life Science Taiwan tracker

Sponsor

Fu Jen Catholic University

Phase

Not applicable

Started

2026-03-19

Last updated

2026-03-27

Condition(s) studied

Cardiovascular SurgeryCardiovascular Disease

Investigational drug(s) / intervention(s)

probiotic supplementation interventionPlacebo supplementation intervention

probiotic supplementation intervention: probiotic supplementation will be administered, while participants continue undergoing standard postoperative care

Placebo supplementation intervention: Undergo routine standard postoperative care with placebo intervention

Study summary

This study aims to investigate the distribution of gut microbiota-derived metabolites, and to evaluate whether postoperative nutritional intervention can modulate the gut-heart metabolic axis, thereby improving metabolic profiles and clinical outcomes.

Eligibility

Sex

ALL

Min age

50 Years

Max age

80 Years

Healthy volunteers

Inclusion Criteria: * Scheduled to undergo cardiovascular surgery * Completed preoperative clinical and imaging evaluations * Willing to provide informed consent * Willing to receive potential probiotic supplementation Exclusion Criteria: * Use of antibiotics, probiotics, or other treatments affecting gut microbiota within 4 weeks * History of major gastrointestinal disease

Primary outcome measure(s)

Trimethylamine-N-oxide — From enrollment to the end of intervention at 3 weeks
Gut microbiota-derived metabolites
Phenylacetylglutamine — From enrollment to the end of intervention at 3 weeks
Gut microbiota-derived metabolites
P-cresyl sulfate — From enrollment to the end of intervention at 3 weeks
Gut microbiota-derived metabolites
Indoxyl sulfate — From enrollment to the end of intervention at 3 weeks
Gut microbiota-derived metabolites

Trial sites (1)

Facility	City	Region	Status
Fu Jen Catholic University Hospital, Fu Jen Catholic University	New Taipei City	Taiwan	Recruiting

More Fu Jen Catholic University trials in Taiwan

Comparing Ultrasonic and Conventional Spirometry in Chronic Respiratory Disease Recruiting

Multimodal Deep Learning Model for Predicting the Apnea-Hypopnea Index in Obstructive Sleep Recruiting

Expression of SLC25A48 in Chronic Obstructive Pulmonary Disease Recruiting

AI-Powered Virtual Human Simulation in Students Starting soon

Use of 3D Printing High-fidelity Craniofacial Manikin to Teach Noninvasive Positive Pressure Ventilation Recruiting

Other trials for the same condition

A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event Recruiting

OCEAN Registry: Obesity and Clock for Elegant Aging Registry Recruiting

To Understand the Self-care Ability of Farmers and Fishermen With CMDs (Hypertension, Heart Disease, Hyperlipidemia, Type 2 Diabetes), Whether They Are Aware of CMDs, Their Treatment Status, Treatment Effectiveness, and Their Ability to Describe Known and Practice the Self-care Content of CMDs. Recruiting

A Phase III Study to Assess the Effect of AZD0780 on LDL-C in Patients With Clinical ASCVD or at Risk for a First ASCVD Event Active, not recruiting

Regional Innovation in Chronic Disease and Elderly Care Recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07497932 on ClinicalTrials.gov ↗ ← All trials in Taiwan