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Clinical Trials in Taiwan / NCT06882733
Recruiting Not applicable

The Immediate Effect of Applying Transcutaneous Electrical Nerve Stimulation (TENS) on Sympathetic Ganglion and Gastrocnemius for Popliteal Blood Flow

NCT06882733 · tracked via the Priya Life Science Taiwan tracker
Sponsor
Kaohsiung Medical University
Phase
Not applicable
Started
2024-12-03
Last updated
2025-07-18

Condition(s) studied

Transcutaneous Electrical Nerve Stimulation (TENS)PoplitealBlood FlowSympathetic Ganglia

Investigational drug(s) / intervention(s)

Transcutaneous Electrical Nerve Stimulation，TENS

Transcutaneous Electrical Nerve Stimulation，TENS: low frequency (4Hz) and sympathetic ganglion(T12.L1.L2) low frequency (4Hz) and gastrocnemius high frequency (80Hz) and sympathetic ganglion(T12.L1.L2) high frequency (80Hz) and gastrocnemius

Study summary

This study aims to evaluate the immediate hemodynamic effects of transcutaneous electrical nerve stimulation (TENS) on the popliteal artery and vein. Vascular issues like PAOD and DVT are common in patients with diabetes, obesity, or immobility due to increased resistance and reduced blood flow. Traditional treatments (medication or surgery) are not always feasible, prompting interest in TENS as an alternative. Although primarily used for pain relief, TENS may enhance blood flow. This research compares different stimulation frequencies (80 Hz vs. 4 Hz) and sites (gastrocnemius muscle vs. thoracolumbar sympathetic ganglia) to identify the most effective configuration.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria: 1. Healthy people 2. Age: 18 years and above (inclusive) 3. Body mass index (BMI) between 18.5 and 24 Exclusion Criteria: 1. Unable to complete two interventions within a week 2. Have contraindications to electrotherapy (for example: metal implants in the body, open wounds, pregnancy, sensory loss) 3. Obvious varicose veins 4. Unable to lie down for about 1 to 2 hours 5. Taking drugs or nutritional supplements that affect autonomic nervous activity or vasodilation (for example: Ginkgo biloba) 6. Smoking 7. Ankle and Ankle Index (ABI) less than 0.9 or greater than 1.3

Primary outcome measure(s)

  • Doppler ultrasound measurement of changes in popliteal fossa blood flow — 45 minutes
    Using Doppler ultrasound to measure blood flow before, during, immediately after, and 15 minutes after electrical stimulation to observe the effects of electrical stimulation on blood flow.

Trial sites (1)

FacilityCityRegionStatus
Kaohsiung Medical University Kaohsiung City Taiwan Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06882733 on ClinicalTrials.gov ↗ ← All trials in Taiwan