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Clinical Trials in Taiwan / NCT06687460
Enrolling by invitation Not applicable

Distal Nerve Electrical Stimulation for Neuromuscular Reinnervation

NCT06687460 · tracked via the Priya Life Science Taiwan tracker
Sponsor
National Cheng-Kung University Hospital
Phase
Not applicable
Started
2024-09-12
Last updated
2026-04-15

Condition(s) studied

Electrical StimulationPeripheral Nerve Regeneration

Investigational drug(s) / intervention(s)

Brief electrical stimulationno nerve electrical stimulation

Brief electrical stimulation: During the nerve micro-reconstruction surgery, electrical stimulation is given to the distal end of the damaged nerve for 30 minutes.

no nerve electrical stimulation: only nerve microsurgical reconstruction, no nerve electrical stimulation

Study summary

During the process of nerve microsurgical reconstruction, 30 minutes of electrical stimulation is applied to the distal end of the damaged nerve to assess its potential benefits for nerve regeneration, functional recovery, slowing down the degeneration at the neuromuscular junction, and preventing muscle atrophy.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Adults aged 18 and older * Acute peripheral nerve rupture between the elbow and wrist * Acute rupture of the median or ulnar nerve * Patients who have signed a valid written consent for surgery and trials * Patients with acute transection or compression of the median nerve or ulnar nerve resulting in impaired hand motor function.Patients with hand motor dysfunction secondary to nerve compression are defined as those who meet all of the following criteria: 1. Evidence of muscle atrophy (including thenar muscles, hypothenar muscles, and interosseous muscles) 2. Positive Froment's sign 3. Positive Wartenberg's sign 4. Presence of ape hand deformity 5. Abnormal findings on electromyography (Needle EMG), such as abnormal insertional activity, increased spontaneous activity, or abnormal motor unit recruitment 6. Classified as Grade IIA, IIB, or III according to the McGowan classification system for severity of nerve compression Exclusion Criteria: * History of injury or other causes leading to muscle and joint dysfunction in the affected area * Patients with radial nerve damage * Diabetes * History of arrhythmia * Stroke * Multiple sclerosis * Hereditary peripheral neuropathy * Amyotrophic lateral sclerosis (ALS) * Patients with a pacemaker * Presence of local infection at the wound site * Pregnant or breastfeeding women * Patients deemed unsuitable for enrollment by a physician

Primary outcome measure(s)

  • NCV/EMG(CMAP,latency) — The third month after surgery.
    The electromyography (EMG) is a diagnostic method used to assess muscle and nerve function, primarily to detect muscle activity and nerve conduction velocity, in order to monitor the recovery of neuromuscular function after surgery. During the EMG examination, the examiner uses electrodes attached to the palm to measure and record the electrophysiological signals of the muscles for further analysis. Through this method, doctors can evaluate the electrophysiological activity of the muscles to assess the reinnervation of distal muscles by the damaged nerves.

Trial sites (1)

FacilityCityRegionStatus
National Cheng Kung University Hospital Tainan Taiwan

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06687460 on ClinicalTrials.gov ↗ ← All trials in Taiwan