Cognitive-motor Training in Parkinson Disease

Condition(s) studied

Investigational drug(s) / intervention(s)

Cognitive-motor training: Cognitive-motor training is that cognitive tasks incorporated into motor tasks.

Conventional physiotherapy: Conventional physiotherapy includes stretching, ROM exercise, strengthening exercise, and eye-hand coordination.

Study summary

Literature reviews showed the cognitive-motor training that combines cognitive tasks may enhance cognitive functions more effectively than individual interventions. Stepping-based cognitive-motor training has been shown to improve cognitive functions, balance, and gait performance in older adults. However, there is insufficient research evidence on the impact and correlation of this training mode on the walking ability, executive functions, and brain activity changes in people with PD. Therefore, this study is designed to investigate the effects of stepping-based cognitive-motor training on the walking ability, executive functions, and brain activity in people with PD.

Eligibility

Primary outcome measure(s)

• Gait variability — Before and after 8 weeks of intervention, as well as 4 weeks after intervention
  Using GAITRite system to measure the coefficient of variation (CV). The mean and standard deviation will be used to calculate the coefficient of variation (CV). CV = standard deviation / mean \* 100%
• Gait speed — Before and after 8 weeks of intervention, as well as 4 weeks after intervention
  Using GAITRite system to measure gait speed
• Step length — Before and after 8 weeks of intervention, as well as 4 weeks after intervention
  Using GAITRite system to measure step length
• Step width — Before and after 8 weeks of intervention, as well as 4 weeks after intervention
  Using GAITRite system to measure step width
• Single support time — Before and after 8 weeks of intervention, as well as 4 weeks after intervention
  Using GAITRite system to measure single support time
• Double support time — Before and after 8 weeks of intervention, as well as 4 weeks after intervention
  Using GAITRite system to measure double support time
• Frontal Assessment Battery — Before and after 8 weeks of intervention, as well as 4 weeks after intervention
  The score ranged from 0 to 18. Higher scores show better executive function.
• Stroop color and word test — Before and after 8 weeks of intervention, as well as 4 weeks after intervention
  Record numbers of corrected color words which the subject responds within 45 sec.
• Digit span test — Before and after 8 weeks of intervention, as well as 4 weeks after intervention
  Digit span test contain forward and backward part. Scores of forward digit span ranges from 0 to 16. Score of backward digit span ranges from 0 to 14. Higher scores indicate better executive function.
• Event-related potential - N2 — Before and after 8 weeks of intervention, as well as 4 weeks after intervention
  Measure event-related potential through electroencephalography under single-task and dual-task paradigm.
• Event-related potential - P300 — Before and after 8 weeks of intervention, as well as 4 weeks after intervention
  Measure event-related potential through electroencephalography under single-task and dual-task paradigm.
• Go/Nogo test — Before and after 8 weeks of intervention, as well as 4 weeks after intervention
  Behavioral test during measuring electroencephalography.
• Trail making test — Before and after 8 weeks of intervention, as well as 4 weeks after intervention
  Trail making test contain part A and part B. Faster completing the test indicates better executive function.

Trial sites (1)

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