Neural Activity Recording: Neural Activity is measured using EEG in all groups. Additionally, in Parkinson's patients, local-field-potentials from deep brain stimulation electrodes are recorded.
Movement Parameter Recording: Gait-related movement parameters are non-invasively recorded using motion capture, accelerometers and electromyography.
Neuromodulation: Neural signals are recorded with the electrodes of the deep brain stimulation device. Parkinson's patients are asked to modulate their neural activity by observing the streamed neural activity and applying mental strategies.
Study summary
This observational study's main goal is to learn more about the neural mechanisms during movement in Parkinson's disease. Furthermore, it aims to inspire personalised treatment options.
Participants will undergo a protocol that involves walking and gait-related motor tasks, such as seated stepping. During the protocol, brain activity will be recorded.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria:
All participants
* must have given informed consent as documented by signature
* agree to comply with the study procedures
Healthy control group
* no neurological, orthopedic, or rheumatologic disease history
* no identified sensory impairment.
* no epilepsy and self-diagnosed acute or chronic psychiatric disorders
Parkinson's Patients
* non-tremor dominant idiopathic PD patients
* presence of postural instability (UPDRS \>1 for postural instability \[17\]), gait disturbance, and absence of other causes of reduced balance
* Implanted with Percept™ PC neurostimulator
* Able to be in the stimulation OFF
Exclusion Criteria:
* Relevant cognitive impairment, with a score on Montréal Cognitive Assessment (MoCA) \< 20
* History of physical or neurological condition that interferes with study procedures
* Social and/or personal circumstances interfering with the ability to come to the session
Primary outcome measure(s)
Cortical activity underlying kinematic gait patterns will be recorded by electroencephalograph of the healthy and Parkinson patients — 30 minutes Using a mobile EEG system to measure neural activity during walking
Electromyography (Delsys®) of the healthy and Parkinson patients — 30 minutes Electrodes will be attached to a representative lower limb muscle, such as the tibialis anterior.
Detect onset of task-related movements detected by an accelerometer that will be placed on the hand and foot of the healthy and the parkinson patients — 30 minutes ZurichMOVE® detects onset of movements
Trial sites (1)
Facility
City
Region
Status
Cereneo
Vitznau
Canton of Lucerne
Recruiting
More Swiss Federal Institute of Technology trials in Switzerland
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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