REducing SPEECH-related Side-effects of Deep Brain Stimulation in Parkinson's Disease Via Automated Speech Analysis

Condition(s) studied

Investigational drug(s) / intervention(s)

Change of stimulation amplitudes in dopaminergic OFF drug state: Change of stimulation amplitudes during experiment in dopaminergic OFF drug state.

Study summary

The investigators' objective is to improve L-dopa sensitive PD-related dysarthria and at the same time reduce DBS-induced speech disorders with the help of automated acoustic analysis in patients with STN-DBS-induced dysarthria.

Eligibility

Primary outcome measure(s)

• Part 1: Identification of the most sensitive and specific speech variables — At visit 1 (baseline visit)
  Identification of the most sensitive and specific speech variables of an automated acoustic analysis method, for STN-DBS-related improvement as well as worsening of speech in PD patients, under the two conditions (dopaminergic ON and OFF drug state). Speech variables will be extracted from the automated acoustic analysis.
• Part 1: Identification of the most sensitive and specific speech variables — At visit 2 (≤4 weeks after visit 1)
  Identification of the most sensitive and specific speech variables of an automated acoustic analysis method, for STN-DBS-related improvement as well as worsening of speech in PD patients, under the two conditions (dopaminergic ON and OFF drug state). Speech variables will be extracted from the automated acoustic analysis.
• Part 2, Speech analysis: Investigation of spatial overlap of volume of tissue activated (VTA) and the corticobulbar/corticospinal tract — 12 months
  Investigation of spatial overlap of tissue activated (VTA) and the corticobulbar/corticospinal tract, in relation to the dysarthria-worsening.
• Part 2, Speech analysis: Investigation of spatial overlap of VTA and the dorsolateral (sensorimotor) STN — 12 months
  Investigation of spatial overlap of VTA and the dorsolateral (sensorimotor) STN in relation to improvement of PD-related dysarthria.
• Part 3: Perceptual speech ratings — At baseline visit
  To test if the model 'perceptual speech ratings' explains subjective improvement of STN-DBS induced dysarthria. Perceptive rating will be performed by three experienced speech therapists, who will rate speech on a visual analogue scale (VAS).
• Part 3: Perceptual speech ratings — At visit 1 (0-6 weeks after baseline)
  To test if the model 'perceptual speech ratings' explains subjective improvement of STN-DBS induced dysarthria. Perceptive rating will be performed by three experienced speech therapists, who will rate speech on a visual analogue scale (VAS).
• Part 3: Perceptual speech ratings — At visit 2 (6-12 weeks after visit 1)
  To test if the model 'perceptual speech ratings' explains subjective improvement of STN-DBS induced dysarthria. Perceptive rating will be performed by three experienced speech therapists, who will rate speech on a visual analogue scale (VAS).
• Part 3: Automated speech analysis — At baseline visit
  To test if the model 'automated speech analysis' explains subjective improvement of STN-DBS induced dysarthria. From the automated speech analysis, only the speech parameters explaining most of the variance in the model from part 2 will be included in the analysis.
• Part 3: Automated speech analysis — At visit 1 (0-6 weeks after baseline)
  To test if the model 'automated speech analysis' explains subjective improvement of STN-DBS induced dysarthria. From the automated speech analysis, only the speech parameters explaining most of the variance in the model from part 2 will be included in the analysis.
• Part 3: Automated speech analysis — At visit 2 (6-12 weeks after visit 1)
  To test if the model 'automated speech analysis' explains subjective improvement of STN-DBS induced dysarthria. From the automated speech analysis, only the speech parameters explaining most of the variance in the model from part 2 will be included in the analysis.

Trial sites (2)

More Insel Gruppe AG, University Hospital Bern trials in Switzerland

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