Crystalloid Fluid Choice and Neurological Outcome in Patients After Subarachnoid Haemorrhage

NCT04043598 · tracked via the Priya Life Science Switzerland tracker

Sponsor

Insel Gruppe AG, University Hospital Bern

Phase

Not applicable

Started

2022-05-24

Last updated

2026-04-29

Condition(s) studied

Subarachnoid HemorrhageCritical IllnessInfusion FluidSodium Disorder

Investigational drug(s) / intervention(s)

0.9% Sodium-chlorideRinger's Lactate

0.9% Sodium-chloride: We will compare two already established treatment protocols: the use of normal saline versus lactated Ringer's for fluid therapy in patients with subarachnoid hemorrhage.

Ringer's Lactate: We will compare two already established treatment protocols: the use of normal saline versus lactated Ringer's for fluid therapy in patients with subarachnoid hemorrhage.

Study summary

Patients with subarachnoid hemorrhage are prone to suffer from dysnatriemia. Evidence shows that hyponatriemia is associated with increased incidence of vasospasm, brain swelling and mortality in these patients. Patients with subarachnoid hemorrhage often require large amounts of iv fluids in order to maintain euvolemia and support cardiocirculatory function. Prior evidence shows that the type of infusion fluid significantly influences blood sodium content. Hence, this study evaluated whether the sodium content of the infusion solution impacts mortality and morbidity in patients with subarachnoid hemorrhage.

Eligibility

Sex

ALL

Min age

16 Years

Max age

—

Healthy volunteers

Inclusion Criteria: All adult patients suffering from non-traumatic subarachnoid haemorrhage. Exclusion Criteria: * Patients with major intra-cranial trauma * Diagnosis of an AV-malformation as the source of subarachnoid hemorrhage on the primary CT/MRI or angiography * More than 24 hours after diagnosis of subarachnoid haemorrhage as diagnosed by cerebral imaging (CT scan or MRI) * Patients with clear limitation to therapy at hospital admission (eg ICU admission for evaluation of organ donation) * Declining of informed consent

Primary outcome measure(s)

Number of patients with clinically relevant vasospasms — From ICU admission until discharge (usually within the first 21 days)
Defined as new neurologic deficit requiring immediate intervention

Trial sites (3)

Facility	City	Region	Status
Department of perioperative Intensive Care Medicine	Sankt Gallen	Canton of St. Gallen	Recruiting
Department of Intensive Care, Bern University Hospital and University of Bern, Bern, Switzerland	Bern	Switzerland	Recruiting
Department of Intensive Care Medicine	Geneva	Switzerland	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04043598 on ClinicalTrials.gov ↗ ← All trials in Switzerland