Cardiac Dysfunction in Childhood Cancer Survivors

NCT03790943 · tracked via the Priya Life Science Switzerland tracker

Sponsor

University of Bern

Phase

Observational

Started

2018-02-13

Last updated

2026-05-29

Condition(s) studied

Cardiac DysfunctionCardiovascular DiseasesChildhood Cancer

Investigational drug(s) / intervention(s)

cardiac assessment

cardiac assessment: Personal history, physical examination including anthropometry with hip/waist-ratio, electrocardiogram, echocardiography, 1-minute-sit-to-stand test, questionnaires on health-related quality of life (SF-36), diet, physical activity, and fatigue

Study summary

This multicenter, prospective cohort study evaluates early cardiac dysfunction in adult survivors of childhood cancer. The hypothesis of this study is that cardiac dysfunction can be detected earlier when using speckle tracking echocardiography as novel echocardiographic technique compared to conventional echocardiography.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

This prospective cohort study is nested within the Childhood Cancer Registry (ChCR), a national, population-based cancer registry that includes all children and adolescents in Switzerland who were diagnosed with cancer at age 0-20 years. It includes patients diagnosed with leukemia, lymphoma, central nervous system tumors, and malignant solid tumours or Langerhans cell histiocytosis. Childhood cancer survivors have survived at least 5 years from cancer diagnosis. Inclusion Criteria: * Registered in the ChCR * Formerly treated at the Department of Pediatric Hematology/Oncology of one of five participating centers * Treated with any chemotherapy and/or chest radiation * Survived ≥ 5 years since most recent cancer diagnosis (primary cancer, relapse(s), secondary cancer) at time of examination * Diagnosed at age ≤ 20 years * ≥ 18 years of age at time of study participation * Resident in Switzerland * Written informed consent Exclusion Criteria: * Study participants will be excluded if they do not meet the above mentioned inclusion criteria or refuse to participate in the study.

Primary outcome measure(s)

Prevalence of cardiac dysfunction — Baseline and longitudinal follow-up where clinically indicated
Conventional echocardiography: left ventricular ejection fraction (%)
Prevalence of cardiac dysfunction — Baseline and longitudinal follow-up where clinically indicated
Speckle tracking echocardiography: longitudinal (LS), circumferential (CS), and radial strain (RS)
Prevalence of impaired exercise capacity — Baseline
Cardiopulmonary exercise testing: peak oxygen consumption, percent-predicted carbon dioxide production
Treatment-related risk factors — Baseline
Cumulative doses of anthracyclines, steroids, and alkylating agents (mg/m2)
Treatment-related risk factors — Baseline
Dose of chest radiation (Gray)

Trial sites (6)

Facility	City	Region	Status
Department of Cardiology, University Hospital Basel	Basel	Canton of Basel-City	Recruiting
Institute of Social and Preventive Medicine, University of Bern	Bern	Canton of Bern	Active Not Recruiting
Department of Cardiology, Inselspital Bern	Bern	Switzerland	Recruiting
Department of Cardiology, University Hospitals of Geneva	Geneva	Switzerland	Recruiting
Department of Cardiology, Lucerne Cantonal Hospital	Lucerne	Switzerland	Recruiting
Department of Cardiology, Cantonal Hospital of St. Gallen	Sankt Gallen	Switzerland	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT03790943 on ClinicalTrials.gov ↗ ← All trials in Switzerland