Menopausal Impact of Opportunistic Salpingectomy for Ovarian Cancer Prevention

Condition(s) studied

Investigational drug(s) / intervention(s)

Opportunistic salpingectomy: Removal of the fallopian tubes at the time of hysterectomy

Study summary

The goal of this clinical trial is to find out whether removing the fallopian tubes at the time of hysterectomy leads to an earlier menopause. The study includes women under 55 years of age who previously underwent hysterectomy as participants in the HOPPSA trial, where they were randomly assigned to either removal of the fallopian tubes or no removal.

The main question is:

• Does removing the fallopian tubes at the time of hysterectomy lead to an earlier menopause? Researchers will compare women who had their fallopian tubes removed during hysterectomy with women who had hysterectomy alone to see whether menopause occurs earlier after tube removal. Age at menopause will be estimated by measuring follicle-stimulating hormone (FSH) in small blood samples collected on a paper card.

Participants will:

* Collect 4-5 drops of blood using a finger prick
* Place the drops on a paper card and mail it to the researchers
* Complete an online questionnaire These steps will be done twice, one year apart.

Eligibility

Primary outcome measure(s)

• Age at menopause — 1 year
  Evaluated using serum follicle-stimulating hormone (FSH) levels analysed in self-sampled dried blood spots. Continuous outcome measured in years. Samples collected twice one year apart.

Trial sites (1)

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