Preoptimisation in Ventral Hernia Surgery

Condition(s) studied

Investigational drug(s) / intervention(s)

preoptimisation programme: The intervention group follows a home-based, multimodal prehabilitation programme targeting physical inactivity, obesity, comorbidities, smoking, and alcohol use. Designed to suit both rural and urban populations in northern Sweden, the programme lasts for a minimum of three months before surgery.

Study summary

The study is a multicentre, single-blinded, randomised controlled trial. Ventral hernia patients with an aperture width between four and eight centimetres are randomised to either participation in a multimodal preoptimisation programme, including interventions to increase physical activity, promote weight loss, and optimise the treatment of comorbidities, or to surgery without structured preoptimisation. The primary endpoint is complications at three months postoperatively. During surgery, biopsies of skin, muscle, and fascia will be collected, along with pre- and postoperative blood samples, to analyse the molecular effects of preoptimisation, particularly in relation to collagen metabolism.

Eligibility

Primary outcome measure(s)

• Complications at three months postoperatively — 3 months postoperatively
  Incidence of surgical and medical (including anaesthetic) complications at 3 months postoperatively.

Trial sites (5)

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