Heparin-binding Protein and Lungedema in ICU Patients.

Condition(s) studied

Study summary

The goal of this single center observational cohort study is to investigate the relationship between physiological measures of lung oedema, and the biomarker Heparin-binding Protein (HBP).

The main questions it aims to answer are:

* Does the concentration of HBP in plasma correlate with measures of lung vascular permeability and extravascular water in the lungs?
* Does the concentration of HBP in plasma correlate with the patient's total accumulated fluid balance?

Researchers will collect blood samples and gather information on lung vascular permeability and extravascular lung water in Intensive care patients who are provided with a hemodynamic surveillance system called PiCCO. The study will include 25 patients.

Eligibility

Primary outcome measure(s)

• Correlation of Heparin-Binding Protein (HBP) and pulmonary vascular permeability Index (PVPI) — Patients are included in the study for as long as the PICCO monitoring is connected but with a maximum of three days.
  The primary outcome is the correlation between concentration of HBP in plasma and PVPI. These values will be visualised using scatterplots with corresponding correlation coefficients. The statistical work up will include a Mann Whitney U test comparing the mean PVPI in the group of patients with HBP above median and the group of patients with HBP below median. Further statistics will include regression analysis depending on the nature of the results.

Trial sites (1)

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