Unbound Cloxacillin Concentrations During Continuous Infusion

Condition(s) studied

Investigational drug(s) / intervention(s)

Unbound cloxacillin concentration: Unbound cloxacillin concentration measured at baseline, after 4h, after 24h and after 48h of continuous infusion.

Study summary

Cloxacillin is the first-line choice for the treatment of severe infections caused by the bacterium Staphylococcus aureus in Sweden. Over the past year, cloxacillin is increasingly administred through continuous infusion. In this study, the free (unbound) concentration of cloxacillin when administered as a continuous infusion will be measured to ensure that the free concentration is neither too high nor too low. A PK/PD model will be developed to predict which dosage of cloxacillin is appropriate for an individual based on age, gender, kidney function, and serum-protein level.

Eligibility

Primary outcome measure(s)

• Free (unbound) cloxacillin concentration — From enrollment to end of follow up at 48 hours

Trial sites (1)