Deep Brain Stimulation for Obsessive-compulsive Disorder

Condition(s) studied

Investigational drug(s) / intervention(s)

Deep brain stimulation: Stimulation through a device implanted bilaterally into deep brain structures.

Study summary

The goal of this clinical trial is to evaluate the treatment method of deep brain stimulation (DBS) in patients diagnosed with severe and treatment-resistant obsessive-compulsive disorder (OCD). DBS will be administered into the brain area of the bed nucleus of stria terminalis (BNST).

The main research questions are:

* Does active DBS in BNST reduce OCD symptoms (primary outcome)?
* Does active DBS in BNST reduce anxiety or depressive symptoms and improve the level of daily function?

The participants will be randomized to active or sham DBS in the BNST for six months and we will measure the outcomes before DBS surgery, and six months post-surgery. After the randomization phase, the participants will enter an open-label phase and receive continuous DBS in BNST. Yearly follow-ups will be conducted. The outcomes will be measured through interviews using validated psychometric scales.

Eligibility

Primary outcome measure(s)

• Yale-Brown Obsessive Compulsive Scale, Y-BOCS — From enrollment to the end of treatment after 6 months.
  Validated psychometric scale that measures symptoms of OCD.

Trial sites (1)

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