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Clinical Trials in Sweden / NCT06267703
Active, not recruiting Observational

Multi-omics Analyses on Etiology and Early Detection of Stomach Cancer Precursor Lesions

NCT06267703 · tracked via the Priya Life Science Sweden tracker
Sponsor
Karolinska Institutet
Phase
Observational
Started
2024-01-01
Last updated
2024-02-21

Condition(s) studied

Chronic Atrophic Gastritis

Investigational drug(s) / intervention(s)

Metabolomic profiling

Metabolomic profiling: Metabolomic profiling using serum samples was performed based on Nightingale Blood Biomarker Analysis platform; Proteomic profiling will be performed by both Scanning SWATH and OLINK® Explore 384 Oncology panel.

Study summary

The overall aim is to utilize multi-omics approach to identify novel etiopathogenesis and early detection biomarkers for stomach cancer precursor lesions. To achieve this aim, first the investigators will use stored serum samples to perform metabolomics profiling among 12,599 twin subjects, among whom 1034 were deemed to have chronic atrophic gastritis based on measured pepsinogen I and II levels. Logistic regression will be used to search for metabolites related to the risk of chronic atrophic gastritis. Second, the investigators will further measure serum proteome by using two quantitatively precise proteomics assays, among the above-mentioned twin subjects. Identified protein biomarkers will be combined with metabolomics biomarkers to create a prediction model for chronic atrophic gastritis. The results will hopefully improve our understanding of the etiological factors and provide promising early detection biomarkers for stomach cancer precursor lesions.

Eligibility

Sex
ALL
Min age
46 Years
Max age
97 Years
Healthy volunteers
No
1. Inclusion Criteria: * participants from the Screening Across the Lifespan (SALT) study within Swedish Twin Registry (STR) who responded to a questionnaire on common diseases and provide a blood sample; * both twins in the pair had to be alive and living in Sweden; * had been enrolled in other STR DNA sampling projects; 2. Exclusion Criteria: * previously declined participation in future studies; * whose blood samples were unavailable or didn't pass initial lab-based QC; * whose samples were unable to link to the available environmental data.

Primary outcome measure(s)

  • Chronic atrophic gastritis — 1 Sep. 2020 to 31 Dec. 2021
    Corpus-dominant chronic atrophic gastritis was characterized by a PGI/PGII ratio of less than 3.

Trial sites (1)

FacilityCityRegionStatus
Karolinska Institutet Solna Stockholm County

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06267703 on ClinicalTrials.gov ↗ ← All trials in Sweden