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Clinical Trials in Sweden / NCT06098586
Recruiting Not applicable

Wrist Denervation Vs Exercise in Wrist Osteoarthritis

NCT06098586 · tracked via the Priya Life Science Sweden tracker
Sponsor
Karolinska Institutet
Phase
Not applicable
Started
2023-11-15
Last updated
2025-02-21

Condition(s) studied

Osteoarthritis Wrist

Investigational drug(s) / intervention(s)

Self-managed exercise therapy programPartial wrist denervation

Self-managed exercise therapy program: Exercise program focusing on functional re-learning and strengthening of the musculoskeletal system with the aim to create a stable wrist that can be used in a pain-free manner in activities of daily living.

Partial wrist denervation: AIN and PIN neurectomy through a dorsal approach as described by Berger (Berger, 1998).

Study summary

A randomized controlled trial comparing partial wrist denervation to a self-managed exercise therapy program in 140 patients with wrist osteoarthritis.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Age ≥ 18 years. * Chronic wrist pain (≥6 months) due to Scapholunate advanced collapse (SLAC) / Scaphoid non-union advanced collapse (SNAC) grade 1-3 osteoarthritis. * Radiological signs of osteoarthritis on posteroanterior and lateral radiograph. Exclusion Criteria: * Previous PIN or AIN neurectomy. * Rheumatoid arthritis or other chronic inflammatory arthritis. * Symptomatic osteoarthritis in the distal radio-ulnar (DRU), Scapho-trapezio-trapezoid (STT) or thumb carpometacarpal (CMC) joints. * Ongoing infection. * Inability to co-operate with the follow-up protocol. * Systemic or intra-articular glucocorticoids or intraarticular PRP or Hyaluronic acid injections in the affected joint within 3 months prior to enrollment.

Primary outcome measure(s)

  • PRWE — 6 months
    Patient Rated Wrist Evaluation (PRWE) score (0-100 (high score worse outcome)) (MacDermid et al., 1998)

Trial sites (2)

FacilityCityRegionStatus
Department of hand surgery, Malmo university hospital Malmö Sweden Recruiting
Department of hand handsurgery, Södersjukhuset Stockholm Sweden Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06098586 on ClinicalTrials.gov ↗ ← All trials in Sweden