The study investigates long-term opioid treatment in patients with chronic non-cancer pain (CNCP). The study aims to prospectively identify predictive factors for work ability and for developing opioid use disorder (according to DSM-5) as well as predictive factors for pain, activity, and health-related quality of life.
It is hypothesized that certain biopsychosocial factors mapped in this study predict patterns of opioid use and the risk for developing OUD for patients with CNCP on long-term opioid therapy. Further, it is hypothesized that certain biopsychosocial factors mapped in this study predict the chance of improved work ability and other treatment benefits of long term opioid therapy in patients with CNCP.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
1. Referral for a first visit to the Pain Centre of Uppsala University Hospital. The following
2. Competent in Swedish
3. Chronic Non-Cancer Pain (pain \> 90 days)
Exclusion Criteria:
1. In active cancer treatment/Cancer-related pain
2. In palliative care
3. Need for interpreter
4. Cognitive impairment of magnitude that will prevent completion of study or ability to give informed consent
Primary outcome measure(s)
Characterization and changes in opioid use disorder — Baseline, 1 year, 2 years, 3 years, 4 years, 5 years As defined in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5).
Measured by:
Structured interview: Modified version of the Swedish Mini International Neuropsychiatric Interview, Part J (Substance use). Response format yes/no.
Mild opioid use disorder = 2-3 symptoms Moderate opioid use disorder = 4-5 symptoms Severe opioid use disorder = 6 or more symptoms
Changes in work ability — Baseline, 1 year, 2 years, 3 years, 4 years, 5 years Self report. Work Ability Index (WAI). The questionnaire covers 7 dimensions:
1. current work ability compared with lifetime best
2. work ability in relation to the demands of the job
3. number of diagnosed illnesses or limiting conditions
4. estimated impairment owing to diseases/illnesses or limiting conditions
5. amount of sick leave during the last year
6. prognosis of work ability in 2 years' time
7. psychological resources.
The dimensions have different scores. A total index is computed ranging from 7 to 49, where higher scores indicate higher work ability. Individual items or sub-scales of WAI may also be used as outcome measures.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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