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Clinical Trials in Sweden / NCT05531240
Recruiting Not applicable

Transurethral Prostate Resection (TURP) vs. Prostate Artery Embolization (PAE)

NCT05531240 · tracked via the Priya Life Science Sweden tracker
Sponsor
Uppsala University
Phase
Not applicable
Started
2022-10-01
Last updated
2026-10-02

Condition(s) studied

Transurethral Resection of Prostate SyndromeProstate HyperplasiaEmbolization, Therapeutic

Investigational drug(s) / intervention(s)

Prostate Artery EmbolizationTransurethral Prostate Resection (TURP)

Prostate Artery Embolization: Prostate Artery Embolization (PAE) is performed by experienced interventional radiologists. The method involves catheterization of the prostate vessels superselectively with two to three French microcatheters. PAE is performed with microspheres of 250 to 400 µm in size.

Transurethral Prostate Resection (TURP): Under general/regional anesthesia, a resectoscope is inserted into the urethra that carries an electric metal loop (monopolar or bipolar diathermy) that is used to cut and extract the prostate tissue.

Study summary

This study focuses on the treatment of benign prostatic hyperplasia which causes lower urinary tract symptoms.

The purpose of the research project is to evaluate PAE in terms of both medical and health economic outcomes. To evaluate whether there are any differences in effect (IPSS), complications, costs and perceived quality of life compared with TUR-P.

Eligibility

Sex
MALE
Min age
45 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Benign prostatic hyperplasia where medical treatment has not helped or for other reasons has not been deemed applicable * IPSS\>=12 * Prostate volume \[40-100\] ml measured via transrectal ultrasound * Peak flow rate (Qmax) \<= 15 ml / s, * Verified obstruction by urodynamic studies (cystometry) * Surgery not contraindicated Exclusion Criteria: * known prostate or bladder cancer * Severe atherosclerosis * Kidney failure eGFR \< 30 * Urethral stricture * Active cystitis or prostatitis * Bladder stone. * Neurogenic bladder disorder * known allergy to iodinated contrast medium

Primary outcome measure(s)

  • Improvement of lower urinary tract symptoms — 24 months
    Assess the change in the lower urinary tract symptoms using the International Prostate Symptom Score (IPSS) questionnaire before and after prostate artery embolization procedure (PAE) compared to transurethral resection of the prostate (TURP)
  • Health care costs — 24 months
    Assess the health care costs after prostate artery embolization procedure (PAE) compared to transurethral resection of the prostate (TURP)

Trial sites (4)

FacilityCityRegionStatus
Helsingborgs Hospital Helsingborg Region Skånes Not Yet Recruiting
Mälarsjukhuset Eskilstuna Region Sörmland Not Yet Recruiting
Lasarettet i Enköping Enköping Region Uppsala Not Yet Recruiting
Region Vastmanland Hospital Västerås Västmanland County Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05531240 on ClinicalTrials.gov ↗ ← All trials in Sweden