Tolerance Results and Immune Mechanisms in Cow´s Milk and/or Hen´s Egg Allergic Children Following Natural Evolution or Oral Immunotherapy

NCT07419243 · tracked via the Priya Life Science Spain tracker

Sponsor

Fundación de Investigación Biomédica - Hospital Universitario de La Princesa

Phase

Phase 1/2

Started

2026-02-18

Last updated

2026-02-27

Condition(s) studied

Food Allergy in Children

Investigational drug(s) / intervention(s)

Oral ImmunotherapyAllergenic food avoidance

Oral Immunotherapy: OIT is a treatment where incremental doses of a food causing allergy to a patient are given until a target maintenance dose is reached, to increase his/her reactivity threshold

Allergenic food avoidance: Allergenic food avoidance is the standard of care for patients allergic to food

Study summary

Allergy to Cow's milk and hen´s egg proteins are the most common causes of food allergies in early childhood and are associated with the occurrence of adverse events that may be life-threatening, quality of life impairment and negative nutritional and health economic impact.

However, contrarily to other food allergy models such as nuts/peanut allergy, milk and egg allergy have greater chances of natural resolution. While around 50% of children may outgrow milk or egg allergy by the age of 5 years old, only 22% of peanut allergic children at the age of 4 years can tolerate this food. However, it is also documented that, at 14 years of age, the persistence of milk and egg allergy still affects around 30% of these children.

Standard of care relies on food avoidance and treatment of accidental reactions, but this approach is unsatisfactory because adverse events and quality of life limitations still remain. Milk and egg Oral Immunotherapy (OIT) is the most promising therapeutic alternative and showed good results to induce Desensitization (ability to tolerate the food while it is regularly taken) but insufficient efficacy to achieve Sustained Unresponsiveness (SU) (ability to tolerate the food after a period of avoidance).

In the day-to-day practice, families and allergists of milk and egg allergic children frequently face the following dilemma: what is the best approach? Keep waiting for natural resolution or embarking in OIT? At the moment, there are only very limited data to guide this decision, specially in children with mild to moderate allergy, that still after 6 years of age withhold relevant chances of naturally outgrowing their allergy.

Our objective is conducting a longitudinal cohort-study of children undergoing food avoidance and children undergoing OIT to assess biomarkers of natural allergy resolution/persistence and OIT Desensitization/Sustained Unresponsiveness trajectories.

Eligibility

Sex

ALL

Min age

4 Years

Max age

17 Years

Healthy volunteers

Inclusion Criteria: NAT-cohort: * Cow´s Milk and/or Hen´s Egg allergic patients 4 to 10 years old * sIgE levels to milk OR egg extracts between 0.35 to 35kUA/L * Positive entry Open food challenge with milk/egg with oFASS5 classification ≥2 with a maximum cumulative dose of up to 4193.7 mg of milk protein or 3110.8 mg of egg white protein * Having a mild to moderate food allergy severity per the Definition of Food Allergy Severity (DEFASE) score (\<13 points) * Having signed the informed consent OIT-cohort: * Patients in the compITO study (NCT06976775) who are undergoing OIT and have achieved full desensitization to the food by month 7 of the study (end of study) * Patients in the compITO study who are undergoing OIT and have achieved partial desensitization (tolerating a dose lower than the total dose, and a minimum of 3 doses above the entry challenge threshold) to the food by month 7 of the study (end of study) * Having signed the informed consent Exclusion Criteria: NAT-cohort: * Positive reaction in the entry open oral food challenge with a baseline Eliciting Dose (ED) 20 below the target ED20 for food. For milk, 23.1 mg (35.7 mg cumulative) of protein, or for egg, 19.5 mg (29.4 mg cumulative) of protein. * Patient desire or medical indication to initiate OIT at any time within 29 months of study entry. * No allergic reaction greater than oFASS5 grade 1 in the baseline challenge for the maximum cumulative programmed doses of 4193.7 mg of milk protein, or 3110.8 mg of egg white protein. * Immunological diseases, immunomodulatory/blocking therapies. * Severe atopic dermatitis according to the SCORing Atopic Dermatitis (SCORAD) classification * Severe allergy, according to a DEFASE score ≥13 * Spirometry values with moderate-to-severe airflow obstruction (FEV1 \<70%) * Poorly controlled asthma according to clinical criteria * Previous OIT for another food * Within the first 3 months of treatment with Subcutaneous Aeroallergen Immunotherapy * Within the first week of treatment with Sublingual Aeroallergen Immunotherapy * Presence or suspicion of Eosinophilic Esophagitis * Non-IgE-mediated allergy to milk or egg * Pregnancy * Significant medical comorbidities (renal, hepatic, or cardiac insufficiency, active infectious diseases, previous or concurrent cancers) * Inability to provide informed consent * Communication or cognitive barriers that prevent adherence to the protocol OIT-cohort: * Patients enrolled in the compITO study who have failed or withdrawn from the study for any reason. * Patients with uncontrolled Atopic Dermatitis or Asthma at the time of enrolment, or who have developed Eosinophilic Esophagitis. * Patients with confirmed pregnancy at the time of enrolment. * Patients who have developed significant medical comorbidities (renal, hepatic, or cardiac insufficiency, active infectious diseases, previous or concurrent cancers) at the time of enrolment. * Inability to provide informed consent. * Communication or cognitive barriers that prevent adherence to the protocol.

Primary outcome measure(s)

Comparison of the proportion of patients achieving SU in the OIT-cohort after 2 years of OIT treatment vs the proportion of patients achieving natural resolution after 2 years of follow up — Month 19 of the study in the OIT-cohort and Month 24 in the NAT-cohort

Trial sites (1)

Facility	City	Region	Status
Hospital Infantil Universitario Niño Jesús. Avenida de Menéndez Pelayo, número 65	Madrid	Madrid	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07419243 on ClinicalTrials.gov ↗ ← All trials in Spain