Nut Consumption and Prevention of Non-communicable Diseases: A Global Individual Participant Data Meta-analysis

Condition(s) studied

Study summary

The relationship between nut consumption and the risk of developing non-communicable diseases (NCDs) has been a subject of growing interest. However, the findings from previous studies have been conflicting for some health outcomes, such as type-2 diabetes, and have been underexplored for other outcomes, such as neurodegenerative diseases. One contributing factor to these inconsistencies lies in the different analytical approaches and confounding factors used across studies. Furthermore, the majority of previous studies have primarily focused on populations in Europe or the United States, potentially limiting the generalizability of the findings to other global regions. The NUTPOOL project aims to address these gaps by conducting an extensive individual participant data (IPD) meta-analysis. This study will evaluate the association between total and specific types of nut consumption and the future risk of NCDs.

Eligibility

Primary outcome measure(s)

• Type-2 diabetes incidence — Minimum of five years of median follow-up
  Medical diagnosis, self-reported or medication check
• CVD incidence — Minimum of five years of median follow-up
  Medical diagnosis, self-reported or medication check
• Coronary health disesase incidence — Minimum of five years of median follow-up
  Medical diagnosis, self-reported or medication check
• Stroke incidence — Minimum of five years of median follow-up
  Medical diagnosis, self-reported or medication check
• Total cancer incidence — Minimum of five years of median follow-up
  Medical diagnosis, self-reported or medication check
• All-cause mortality rate — Minimum of five years of median follow-up
  National death registry, self-reported or medication check
• CVD-mortality rate, — Minimum of five years of median follow-up
  National death registry, self-reported or medication check
• Cancer-mortality rate — Minimum of five years of median follow-up
  National death registry, self-reported or medication check

Trial sites (2)

More Institut Investigacio Sanitaria Pere Virgili trials in Spain

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