Ireland
--:--IST
Recruiting Observational

Impact of Endometrial Compaction on Reproductive Outcomes After Cryotransfer of Euploid Embryos in a Natural Cycle

NCT05960370 · tracked via the Priya Life Science Spain tracker
Phase
Observational
Started
2022-06-15
Last updated
2024-10-03

Condition(s) studied

Infertility Due to Nonimplantation

Investigational drug(s) / intervention(s)

Observational non intervention study

Observational non intervention study: An additional control scan will be performed vaginally the day of the embryo transfer. Rest of follow up and treatment will be executed as usually.

Study summary

Multicenter prospective observational cohort study, comparing ongoing pregnancy rates in natural cycles for euploid embryo transfer in patients who present endometrial compaction at the time of the transfer versus those who have a stable or greater endometrial thickness with respect to the estrogenic phase.

Eligibility

Sex
FEMALE
Min age
18 Years
Max age
50 Years
Healthy volunteers
Accepted
Inclusion Criteria: * Aged 18 to 50 years * Primary or secondary infertility * Normal uterine cavity * Endometrial preparation in a modified natural cycle for single embryo transfer * Embryo in blastocyst state from own oocyte or oocyte donation cycles, who had normal results on preimplantation genetic testing for aneuploidy (PGT-A) via trophectoderm biopsy. Exclusion Criteria: * Uterine or endometrial disease (multiple myomatosis \[\>3 fibroids of \> 3 cm\], adenomyosis, Asherman syndrome) * Difficulties in correctly measuring endometrial thickness due to a retroverted or tilted uterus * History of recurrent implantation failure (3 or more transferred blastocysts of good quality, from their own oocyte \[\<35 years\] or oocyte donation); recurrent early Pregnancy Loss (the loss of two or more pregnancies before 10 weeks of gestational age. * Suboptimal endometrial response (endometrium \< 6 mm on the day of ovulation triggering).

Primary outcome measure(s)

  • Ongoing pregnancy rate — 8-10 weeks gestational age.
    Presence of an intrauterine pregnancy with positive embryo heartbeat as seen by sonography at 8-10 weeks gestational age.

Trial sites (1)

FacilityCityRegionStatus
Instituto Bernabeu Madrid Spain Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05960370 on ClinicalTrials.gov ↗ ← All trials in Spain