Somapacitan: Somapacitan 0.24 milligrams per kilograms per week (mg/kg/week) will be administered subcutaneously (s.c.) using PDS290 pen-injector.
Study summary
The purpose of this study is to find out if somapacitan is safe and how well somapacitan works in children either born small for gestational age or with Turner syndrome, Noonan syndrome or idiopathic short stature. Somapacitan is a new growth hormone medicine for treatment of low level of growth hormone. The study will last for about 3 years. During the study, the participants will be treated with somapacitan once a week. Somapacitan can be injected anytime during the day. The study doctor or nurse will show how to inject somapacitan, so that the participant knows how to do it at home.
Eligibility
Sex
ALL
Min age
10 Years
Max age
18 Years
Healthy volunteers
No
Inclusion Criteria:
Applicable to children with SGA:
* Born small for gestational age (birth length below -2 SDS OR birth weight below -2 SDS OR both) (according to national standards).
* Age:
\- Male participants: Age equal to or above 11.0 years and below 18.0 years at screening.
\- Female participants: Age equal to or above 10.0 years and below 18.0 years at screening.
* Open epiphyses; defined as bone age less than (\<) 14 years for females and bone age \< 16 years for males.
* For Growth Hormone (GH) treatment naïve participants: Impaired height defined as at least 2.5 standard deviations below the mean height for chronological age and sex at screening according to the standards of Centers for Disease Control and Prevention.
Applicable to children with TS:
• Diagnosis of TS according to local clinical practice.
* Age:
\- Female participants: Age equal to or above 10.0 years and below 18.0 years at screening.
* Open epiphyses; defined as bone age \< 14 years for females and bone age \< 16 years for males.
* For GH treatment naïve participants: Impaired height defined as at least 2.0 standard deviation below the mean height for chronological age and sex at screening according to the standards of Centers for Disease Control and Prevention.
* For GH treatment naïve participants: Confirmed diagnosis of TS by 30-cell (or more) lymphocyte chromosomal analysis or confirmation of TS and TS mosaicism using comparative genomic hybridization (CGH)-array.
Applicable to children with NS:
* Diagnosis of NS according to local clinical practice.
* Age:
* Male participants: Age equal to or above 11.0 years and below 18.0 years at screening.
* Female participants: Age equal to or above 10.0 years and below 18.0 years at screening.
* Open epiphyses; defined as bone age \< 14 years for females and bone age \< 16 years for males.
* For GH treatment naïve participants: Clinical diagnosis of NS according to van der Burgt score list and genetic test result or confirmed mutation in any of the genes associated with NS before allocation.
Applicable to children with ISS:
* Age:
\- Male participants: Age equal to or above 11.0 years and below 18.0 years at screening.
\- Female participants: Age equal to or above 10.0 years and below 18.0 years at screening.
* Open epiphyses; defined as bone age \< 14 years for females and bone age \< 16 years for males.
* For GH treatment naïve participants: Impaired height defined as at least 2.5 standard deviations below the mean height for chronological age and sex at screening
* For GH treatment naïve participants: Normal GH secretion (GH peak above 7 ng/mL) during GH stimulation test performed within 18 months prior to screening.
* For GH treatment naïve participants: Bone age not delayed more than 2 years compared to chronological age at screening.
Exclusion Criteria:
* Children with suspected or confirmed growth hormone deficiency according to local practice.
* Children diagnosed with diabetes mellitus or screening values from the central laboratory.
* Fasting plasma glucose above or equal to 126 milligrams per deciliter (mg/dL) \[7.0 millimoles per litre (mmol/L)\] or
* Glycated hemoglobin (HbA1c) above or equal to 6.5%.
* Current inflammatory diseases requiring systemic corticosteroid treatment for longer than 2 consecutive weeks within the last 3 months prior to screening.
* Children requiring inhaled glucocorticoid therapy at a dose greater than 400 micrograms per day (µg/day) of inhaled budesonide or equivalent (i.e., 250 µg/day for fluticasone propionate) for longer than 4 consecutive weeks within the last 12 months prior to screening.
* History or known presence of malignancy including intracranial tumours.
Applicable to children with SGA:
• Any known or suspected clinically significant abnormality likely to affect growth or the ability to evaluate growth with height, such as, but not limited to:
* Poorly controlled or uncontrolled hormonal deficiencies.
* Known chromosomal aneuploidy or significant gene mutations causing medical 'syndromes' with short stature, including but not limited to Laron syndrome, Prader-Willi syndrome, Russell-Silver Syndrome, skeletal dysplasias, abnormal short stature homeobox (SHOX) gene analysis or absence of GH receptors.
Applicable to children with TS:
• Any known or suspected clinically significant abnormality likely to affect growth or the ability to evaluate growth with height, such as, but not limited to:
* Known family history of skeletal dysplasia.
* Significant spinal abnormalities including but not limited to scoliosis, kyphosis and spina bifida variants.
* Any other disorder that can cause short stature such as, but not limited to nutritional disorders, chronic systemic illness and chronic renal disease.
* Mosaicism below 10%.
* TS with Y-chromosome mosaicism where gonadectomy has not been performed.
* New York Heart Association (NYHA) class II or above or requiring medication for any heart condition.
Applicable to children with NS:
• Any known or suspected clinically significant abnormality likely to affect growth or the ability to evaluate growth with height, such as, but not limited to:
* Known family history of skeletal dysplasia.
* Significant spinal abnormalities including but not limited to scoliosis, kyphosis and spina bifida variants.
* Any other disorder that can cause short stature such as, but not limited to nutritional disorders, chronic systemic illness and chronic renal disease.
* Noonan-related disorders including but not limited to: Noonan syndrome with multiple lentigines (formerly called 'LEOPARD' syndrome), Noonan syndrome with loose anagen hair, cardiofaciocutaneous syndrome (CFC), Costello syndrome, neurofibromatosis type 1 (NF1) and Legius syndrome.
Applicable to children with ISS:
• Any known or suspected clinically significant abnormality likely to affect growth or the ability to evaluate growth with height, such as, but not limited to:
* Known family history of skeletal dysplasia.
* Significant spinal abnormalities including but not limited to scoliosis, kyphosis and spina bifida variants.
* Any other disorder that can cause short stature such as, but not limited to nutritional disorders, chronic systemic illness and chronic renal disease.
* Poorly controlled or uncontrolled hormonal deficiencies.
* Known chromosomal aneuploidy or significant gene mutations causing medical 'syndromes' with short stature, including but not limited to Laron syndrome, Prader-Willi syndrome, Russell-Silver Syndrome, skeletal dysplasias, abnormal SHOX gene analysis or absence of GH receptors.
Primary outcome measure(s)
Number of Adverse Events (AEs) Reported in Children Born Small for Gestational Age- Weeks 0 to 26 — From baseline (Week 0) to Week 26 This outcome measure reported number of AEs in children with short stature for indication SGA. Children with SGA are born small for gestational age with insufficient catch-up growth by 2 years of age or older. An AE is any untoward medical occurrence in a clinical study participant that is temporally associated with the use of study treatment, whether or not considered related to the study treatment. An AE can therefore be any unfavourable and unintended sign (including an abnormal laboratory finding), symptom or disease (new or exacerbated) temporally associated with the use of an study treatment.
Number of Adverse Events Reported for Turner Syndrome (TS)- Weeks 0 to 26 — From baseline (Week 0) to Week 26 This outcome measure reported number of AEs in participants with short stature for indication TS. TS is a chromosomal disorder which leads to short stature. An AE is any untoward medical occurrence in a clinical study participant that is temporally associated with the use of study treatment, whether or not considered related to the study treatment. An AE can therefore be any unfavourable and unintended sign (including an abnormal laboratory finding), symptom or disease (new or exacerbated) temporally associated with the use of an study treatment.
Number of Adverse Events Reported for Noonan Syndrome- Weeks 0 to 26 — From baseline (Week 0) to Week 26 This outcome measure reported number of AEs in participants with short stature for indication NS which is a genetically heterogeneous developmental disorder characterized by postnatally reduced growth and other major disorders. An AE is any untoward medical occurrence in a clinical study participant that is temporally associated with the use of study treatment, whether or not considered related to the study treatment. An AE can therefore be any unfavourable and unintended sign (including an abnormal laboratory finding), symptom or disease (new or exacerbated) temporally associated with the use of an study treatment.
Number of Adverse Events Reported for Idiopathic Short Stature (ISS)- Weeks 0 to 26 — From baseline (Week 0) to Week 26 This outcome measure reported number of AEs in participants with short stature for indication ISS. ISS describes short children with normal GH secretion. ISS is a condition in which the height of the individual is more than 2 standard deviations below the corresponding mean height for a given age, sex and population, without evidence of systemic, endocrine, nutritional or chromosomal abnormalities. An AE is any untoward medical occurrence in a clinical study participant that is temporally associated with the use of study treatment, whether or not considered related to the study treatment. An AE can therefore be any unfavourable and unintended sign (including an abnormal laboratory finding), symptom or disease (new or exacerbated) temporally associated with the use of an study treatment.
Trial sites (18)
Facility
City
Region
Status
Univ of AL at Birmingham_BRM
Birmingham
Alabama
Sutter Valley Med Fdt Ped Endo
Sacramento
California
Rocky Mt Ped and Endo
Centennial
Colorado
Childrens National Medical Ctr
Washington D.C.
District of Columbia
Rocky Mt Clin Res, LLC
Idaho Falls
Idaho
Children's Minnesota
Saint Paul
Minnesota
University Malaya Medical Centre
Lembah Pantai
Kuala Lumpur
Hospital Al-Sultan Abdullah UiTM
Bandar Puncak Alam
Selangor
Erasmus MC
Rotterdam
Netherlands
Kliniczny Szpital Wojewodzki nr 2 im. Sw. Jadwigi Krolowej w Rzeszowie
Rzeszów
Podkarpackie Voivodeship
UCK, Klinika Pediatrii, Diabetologii i Endokrynologii,
Gdansk
Poland
Instytut Centrum Zdrowia Matki Polki
Lodz
Poland
Kliniczny Szpital Wojewodzki nr 2 im. Sw. Jadwigi Krolowej w Rzeszowie
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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