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Clinical Trials in Spain / NCT04905238
Enrolling by invitation Not applicable

Obstructive Sleep Apnea and Biomarkers of Alzheimer's Disease

NCT04905238 · tracked via the Priya Life Science Spain tracker
Sponsor
Alberto Alonso Fernandez
Phase
Not applicable
Started
2020-07-31
Last updated
2025-05-01

Condition(s) studied

Sleep Apnea, Obstructive

Investigational drug(s) / intervention(s)

Continuous positive airway pressure

Continuous positive airway pressure: Continuous positive airway pressure

Study summary

Clinical trial on the effect of continuous positive pressure (CPAP). Objectives: 1) To compare biomarkers of Alzheimer's disease in plasma samples from patients with Obstructive sleep apnea (OSA) and without OSA. 2) To determine if CPAP reduces biomarkers of Alzheimer's disease in plasma samples.

Eligibility

Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
Accepted
Inclusion Criteria: * Cases: patients with AHI \> 30/h * Controls: subjects with AHI \< 5/h and Epworth \<10 Exclusion Criteria: * Epworth\>18 * BMI\<40Kg/M2 * Arterial Hypertension * Diabetes Mellitus * Cerebrovascular disease * Ischemic heart disease * Cardiac arrhythmia * Chronic cardiovascular diseases * Daytime Oxygen saturation\>95% * Risk professions (professional drivers) * Concomitant treatment with antihypertensives, statins, antidiabetics, beta- blockers or systemic corticosteroids. * Pretreatment with CPAP. * Participation in another clinical trial thirty days prior to randomization * Abnormal values of a cognitive test.

Primary outcome measure(s)

  • Change from baseline in β-amyloid 40 (Aβ-40 and/or Aβ42) concentration — 4 months
    To compare the change in Aβ-40 and/or Aβ42 levels between the patients allocated to CPAP group and the control group
  • β-amyloid 40 (Aβ-40 and and/or Aβ42) concentration in OSA and in non-OSA patients — Baseline
    To compare Aβ-40 and/or Aβ42 levels between OSA and non-OSA patients

Trial sites (2)

FacilityCityRegionStatus
Hospital Son Espases Palma Balearic Islands
Hospital Son Llatzer Palma Balearic Islands

Other trials for the same condition

A Study of Eloralintide (LY3841136) in Participants With Obstructive Sleep Apnea and Obesity or Overweight Recruiting
Effect of CPAP Versus APAP in Patients With Obesity Undergoing Bariatric Surgery Protocol Starting soon
CPAP Effect on the Polycythemia in Patients With Obstructive Sleep Apnea Recruiting
Normotensive OSA Patients With Dipper Circadian Blood Pressure Pattern Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04905238 on ClinicalTrials.gov ↗ ← All trials in Spain