Myocardial Ischemia Without Obstructive Coronary Stenoses

Condition(s) studied

Investigational drug(s) / intervention(s)

Invasive coronary endothelium-dependent and non-endothelium-dependent physiological assessment: Coronary hemodynamics and vessel anatomical measures obtained during adenosine and acetylcholine evaluation with a dedicated physiology wire

Study summary

Coronary-related myocardial ischemia can result from obstructive epicardial stenosis or non-obstructive causes including coronary microcirculatory dysfunction and vasomotor disorders. This prospective study has been created in order to provide knowledge in the field of non-obstructive coronary artery disease.

Eligibility

Primary outcome measure(s)

• Patient-oriented composite outcome — Up to 5 years
  Incidence of a patient-oriented composite outcome, a composite of any death, nonfatal myocardial infarction, any ischemia-driven revascularization or hospitalization due to unstable angina pectoris
• Vessel-oriented composite outcome — Up to 5 years
  Incidence of a vessel-oriented composite outcome, a composite of cardiac death, target-vessel related myocardial infarction or target-vessel revascularization
• Patient symptoms burden — Up to 12 months
  Change in the Seattle questionnaire of angina scoring, associated to stratified medical treatment. Minimum is 0 and maximum is 100 and lower scores indicate worse outcome

Trial sites (1)

More Hospital San Carlos, Madrid trials in Spain

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