Ireland
--:--IST
Latest
Clinical Trials in South Korea / NCT07851025
Recruiting Phase 3

Torvutatug Samrotecan Plus Bevacizumab as First-line Maintenance in Homologous Recombination Deficiency (HRD) Negative Advanced Epithelial Ovarian Cancer

NCT07851025 · tracked via the Priya Life Science South Korea tracker
Phase
Phase 3
Started
2026-09-16
Last updated
2026-10-01

Condition(s) studied

Epithelial Ovarian Cancer

Investigational drug(s) / intervention(s)

Torvutatug samrotecan →Bevacizumab →

Torvutatug samrotecan: Antibody drug conjugate

Bevacizumab: Monoclonal antibody inhibitor of Vascular Endothelial Growth Factor

Study summary

This study will evaluate the efficacy, safety and tolerability of Torvutatug samrotecan (torvu-sam) in combination with bevacizumab compared with bevacizumab monotherapy as first line maintenance treatment in patients with Homologous Recombination Deficient (HRD) negative advanced ovarian cancer.

Eligibility

Sex
FEMALE
Min age
18 Years
Max age
—
Healthy volunteers
No
Key Inclusion Criteria: * Participants with newly diagnosed FIGO Stage III/IV, histologically confirmed epithelial high-grade ovarian, fallopian tube or primary peritoneal carcinoma * Provision of an archival FFPE tumour sample * Participants who have completed at least 6 cycles and a maximum of 8 cycles of first-line Platinum-based chemotherapy (PBC) prior to randomisation * Participants must have received a minimum of 3 cycles of bevacizumab in combination with the 3 last cycles of PBC, prior to randomisation * Participants who have completed cytoreductive surgery or have inoperable disease * Participants with non-progressive disease upon completion of front-line induction therapy * HRD negative tumour Key Exclusion Criteria: * Participants with tumours of non-epithelial origin, borderline tumours, or low-grade epithelial tumours. * Participants with history of (non-infectious) ILD/pneumonitis that required steroids or supplemental oxygen, or has current ILD/pneumonitis, or where suspected ILD/pneumonitis cannot be ruled out by imaging at Screening * Participants with non-healing wound, active ulcer, or bone fracture * Participants with evidence of active or ongoing bowel obstruction * Prior exposure to any FRα-targeted therapy, including MIRV, or any TOP1i Antibody-drug Conjugate (ADC)

Primary outcome measure(s)

Trial sites (186)

FacilityCityRegionStatus
Research Site Tampa Florida Not Yet Recruiting
Research Site Baltimore Maryland Not Yet Recruiting
Research Site Billings Montana Not Yet Recruiting
Research Site Cleveland Ohio Not Yet Recruiting
Research Site Buenos Aires Argentina Not Yet Recruiting
Research Site Buenos Aires Argentina Not Yet Recruiting
Research Site Capital Federal Argentina Not Yet Recruiting
Research Site Ciudad de Buenos Aires Argentina Not Yet Recruiting
Research Site Ciudad de Buenos Aires Argentina Not Yet Recruiting
Research Site Córdoba Argentina Not Yet Recruiting
Research Site Córdoba Argentina Not Yet Recruiting
Research Site Córdoba Argentina Not Yet Recruiting
Research Site Rosario Argentina Not Yet Recruiting
Research Site Salta Argentina Not Yet Recruiting
Research Site Santa Fe Argentina Not Yet Recruiting
Research Site Viedma Argentina Not Yet Recruiting
Research Site Auchenflower Australia Not Yet Recruiting
Research Site Benowa Australia Not Yet Recruiting
Research Site Hobart Australia Not Yet Recruiting
Research Site Kingswood Australia Not Yet Recruiting
Research Site Nedlands Australia Not Yet Recruiting
Research Site Port Macquarie Australia Not Yet Recruiting
Research Site Randwick Australia Not Yet Recruiting
Research Site Richmond Australia Not Yet Recruiting
Research Site Toorak Gardens Australia Not Yet Recruiting
Research Site Wollongong Australia Not Yet Recruiting
Research Site Fortaleza Brazil Not Yet Recruiting
Research Site Itajaí Brazil Not Yet Recruiting
Research Site Jaú Brazil Not Yet Recruiting
Research Site Natal Brazil Not Yet Recruiting
Research Site Porto Alegre Brazil Not Yet Recruiting
Research Site Rio de Janeiro Brazil Not Yet Recruiting
Research Site Salvador Brazil Not Yet Recruiting
Research Site São Paulo Brazil Not Yet Recruiting
Research Site São Paulo Brazil Not Yet Recruiting
Research Site São Paulo Brazil Not Yet Recruiting
Research Site Dobrich Bulgaria Not Yet Recruiting
Research Site Plovdiv Bulgaria Not Yet Recruiting
Research Site Shumen Bulgaria Not Yet Recruiting
Research Site Sofia Bulgaria Not Yet Recruiting

+ 146 more sites — see the full list on the official registry below.

On this site

📄 Avastin (bevacizumab) drug profile →

More AstraZeneca trials in South Korea

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07851025 on ClinicalTrials.gov ↗ ← All trials in South Korea