Effect of Individualized Positive End-expiratory Pressure (PEEP) in Patients Who Have an Intrinsic PEEP During One-lung Ventilation

Condition(s) studied

Investigational drug(s) / intervention(s)

PEEP0: PEEP 0 (zero) means off-PEEP on the anesthesia machine.

PEEP5: PEEP5 means setting the PEEP to 5 cmH2O on the anesthesia machine.

PEEPi: PEEPi (individualized PEEP) means setting the PEEP to 70% of intrinsic PEEP on the anesthesia machine.

Study summary

This study investigates the effects of three extrinsic PEEP settings-5 cmH2O, 0 cmH2O, and an individualized PEEP (70% of the measured intrinsic PEEP)-on intrinsic PEEP and hemodynamic stability in patients with intrinsic PEEP undergoing lung resection surgery, using a randomized, crossover design.

Eligibility

Primary outcome measure(s)

• Intrinsic positive end-expiratory airway pressure — During a 30-minute period from the start of one-lung ventilation to the completion of the intervention
  During one-lung ventilation, each patient will randomly receive three PEEP interventions: 0 cmH2O, 5 cmH2O, and the 70% value of intrinsic PEEP. After each 5-minute intervention, intrinsic PEEP will be measured by the anesthesia machine.
• Stroke volume — During a 30-minute period from the start of one-lung ventilation to the completion of the intervention
  During one-lung ventilation, each patient will randomly receive three PEEP interventions: 0 cmH2O, 5 cmH2O, and the 70% value of intrinsic PEEP. After each 5-minute intervention, Stroke volume will be measured by an arterial pressure-based cardiac output monitor.

Trial sites (1)

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