OPTIA-AF Trial: Rhythm-Guided Antithrombotic Strategy After AF Ablation

1. Inclusion Criteria * Participants must meet all of the following criteria: * Age ≥18 years. * Documented history of atrial fibrillation (paroxysmal or persistent). * Successful catheter ablation for atrial fibrillation performed within the previous 3-6 months. * Maintenance of sinus rhythm after ablation, confirmed by follow-up electrocardiography or rhythm monitoring. * History of percutaneous coronary intervention (PCI) with drug-eluting stent (DES) implantation. * Completion of the recommended duration of dual antiplatelet therapy (DAPT) following PCI. * Currently receiving oral anticoagulation therapy with a non-vitamin K antagonist oral anticoagulant (NOAC). * Clinically stable and considered eligible for long-term antithrombotic therapy adjustment by the treating physician. * Ability to understand the study procedures and provide written informed consent. 2. Exclusion Criteria * Participants will be excluded if any of the following criteria are present: * Recurrent atrial fibrillation documented after the index ablation procedure requiring repeat ablation or antiarrhythmic escalation. * Presence of mechanical heart valve or moderate-to-severe mitral stenosis. * Indication for long-term anticoagulation independent of atrial fibrillation (e.g., venous thromboembolism, mechanical valve). * Recent acute coronary syndrome or PCI within the past 3 months. * Planned coronary revascularization or cardiac surgery. * History of intracranial hemorrhage or other major bleeding that contraindicates antithrombotic therapy. * Severe renal dysfunction (e.g., estimated glomerular filtration rate \<30 mL/min/1.73 m²). * Severe hepatic dysfunction associated with coagulopathy. * Known hypersensitivity or contraindication to aspirin or NOAC therapy. * Pregnancy or breastfeeding. * Life expectancy less than 1 year due to non-cardiovascular comorbidities. * Participation in another interventional clinical trial that may interfere with the study outcomes.