Clinical Trials in South Korea / NCT07370818
Starting soon
Phase 2
To Evaluate the Efficacy and Safety of JPI-547 in Combination With Bevacizumab as Maintenance Therapy in Relapsed Ovarian Cancer
NCT07370818 · tracked via the Priya Life Science South Korea tracker
Condition(s) studied
Ovarian Cancer
Investigational drug(s) / intervention(s)
JPI-547: taking JPI-547
Bevacizumab: administration Bevacizumab
Study summary
This study aims to to evaluate the efficacy, safety, and pharmacokinetics of JPI- 547 with bevacizumab maintenance therapy in relapsed ovarian cancer patients
Eligibility
Inclusion Criteria:
* Histologically or cytologically confirmed recurrent ovarian cancer, fallopian tube cancer, or primary peritoneal cancer \[High-grade serous carcinoma (HGSC), Grade 2/3 endometrioid carcinoma\]
* Patients whose BRCA 1/2 gene mutation status and/or Homologous Recombination Deficiency (HRD) status.
* Patients who received platinum-based chemotherapy followed by PARP inhibitor maintenance therapy,
* Patients who had received chemotherapy before participating in the clinical trial and responded to platinum-based chemotherapy.
* Those with Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1.
* Individuals with confirmed adequate hematological, renal, and hepatic function (laboratory tests may be repeated once during the screening period)
Exclusion Criteria:
* Patients with a history of severe drug hypersensitivity or hypersensitivity to the investigational drug, its components, or drugs within the same class.
* Individuals with dysphagia
* Patients with a confirmed specific medical history or a past surgical history.
* Patients with specific comorbidities or medical abnormalities.
* Pregnant women, lactating women, or women of childbearing potential who do not agree to use appropriate contraception during the clinical trial period and for 24 weeks after administration of the investigational medicinal product.
* Those who have administered other investigational products or have received investigational medical device procedures within 4 weeks of the baseline
* Other patients who are inappropriate or unable to participate in this clinical study at the discretion of the investigator.
Primary outcome measure(s)
- Part A: Maximum tolerated dose (MTD) and recommended dose (RD)(RP2D) — The dose-limiting toxicity evaluation window is 21 days
- Part B: Progression free survival(PFS) — From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 74 months.
Trial sites (1)
| Facility | City | Region | Status |
|---|---|---|---|
| Severance Hospital, Yonsei Cancer Center, Yonsei University College of Medicine | Seoul | South Korea |
On this site
📄 Avastin (bevacizumab) drug profile →More Onconic Therapeutics Inc. trials in South Korea
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Official registry record
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT07370818 on ClinicalTrials.gov ↗ ← All trials in South Korea