Resting Full-cycle Ratio (RFR)-Guided Revascularization
Condition(s) studied
Investigational drug(s) / intervention(s)
Resting full-cycle ratio (RFR)-guided revascularization: The decision of coronary intervention is based on an RFR cut-value of 0.89. If RFR ≤ 0.89, target lesion will be revascularized, and if RFR \> 0.89, PCI will be deferred. However, even if RFR ≤ 0.89, PCI can be deferred if the RFR gradient of the lesion ≤ 0.02, or if the diffused type of stenosis, because physiological gain is expected to be very low.
Fractional flow ratio (FFR)-guided revascularization: Study participants of FFR-guided PCI arm will be selected from a large-scaled, ongoing FFR registry. The decision of coronary intervention is based on an FFR cut-value of 0.80. If FFR ≤ 0.80, target lesion will be revascularized, and if RFR \> 0.80, PCI will be deferred.
Study summary
The purpose of this study is to compare the clinical outcomes of a 2-year follow-up to determine whether RFR-guided coronary intervention is non-inferior to FFR-guided coronary intervention in patients with intermediate coronary stenosis.
Eligibility
Primary outcome measure(s)
- A composite of death from any cause, non-fatal myocardial infarction, or unplanned revascularization — At 2-year
Trial sites (1)
| Facility | City | Region | Status |
|---|---|---|---|
| Sejong general hospital, 91-121 Sosa 2-Dong, Sosa-Gu | Bucheon-si | Gyeonggi-do | Recruiting |
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Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT06075160 on ClinicalTrials.gov ↗ ← All trials in South Korea