A Study of JNJ-90014496 in Participants With B-Cell Non-Hodgkin Lymphoma
Condition(s) studied
Investigational drug(s) / intervention(s)
JNJ-90014496: JNJ-90014496, an autologous dual targeting chimeric antigen receptor (CAR) - T cell therapy targeting Cluster of differentiation (CD)20 and CD19.
Study summary
This is a Phase 1b/2, multicenter, open-label, study of JNJ-90014496, an autologous dual targeting chimeric antigen receptor (CAR) T-cell therapy targeting both cluster of differentiation (CD) CD20 and CD19, for the treatment of adult participants with relapsed or refractory (r/r) B-Cell non-Hodgkin lymphoma (B-NHL) or frontline high-risk diffuse large B-cell lymphoma (DLBCL).
Eligibility
Primary outcome measure(s)
- Phase 1b: Occurrence of Adverse Events (AEs) [Safety and Tolerability] — Up to 15 Years post JNJ-90014496 infusion
Occurrence of any AEs, including dose limiting toxicities (DLTs). - Phase 2: Overall Response (OR) As Assessed by Independent Review Committee (IRC) — Up to 6 months post last participant's JNJ-90014496 infusion
Overall response is defined as a PR or CR at any point between the time of JNJ-90014496 infusion until PD or start of subsequent anti-lymphoma therapy, whichever occurs first (per Lugano 2014 guidelines).
Trial sites (32)
| Facility | City | Region | Status |
|---|---|---|---|
| City of Hope | Duarte | California | |
| Colorado Blood Cancer Institute | Denver | Colorado | |
| University of Iowa Hospital and Clinics | Iowa City | Iowa | |
| University of Kentucky Medical Center | Lexington | Kentucky | |
| Rutgers Cancer Institute of New Jersey | Piscataway | New Jersey | |
| Levine Cancer Institute | Charlotte | North Carolina | |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | |
| University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania | |
| Greco Hainesworth Tennessee Oncology Centers for Research | Nashville | Tennessee | |
| Sarah Cannon Research Institute | Nashville | Tennessee | |
| St. David's South Austin Medical Center | Austin | Texas | |
| MD Anderson Cancer Center | Houston | Texas | |
| Texas Transplant Institute | San Antonio | Texas | |
| Swedish Cancer Institute | Seattle | Washington | |
| St Vincents Hospital Melbourne | Fitzroy | Australia | |
| The Alfred Hospital | Melbourne | Australia | |
| Fiona Stanley Hospital | Murdoch | Australia | |
| Calvary Mater Newcastle Hospital | Waratah | Australia | |
| Princess Margaret Cancer Centre University Health Network | Toronto | Ontario | |
| Rigshospitalet | Copenhagen | Denmark | |
| Odense University Hospital | Odense | Denmark | |
| Erasmus MC | Rotterdam | Netherlands | |
| UMC Utrecht | Utrecht | Netherlands | |
| Seoul National University Hospital | Seoul | South Korea | |
| Asan Medical Center | Seoul | South Korea | |
| Samsung Medical Center | Seoul | South Korea | |
| Hosp Univ Vall D Hebron | Barcelona | Spain | |
| Hosp Clinic de Barcelona | Barcelona | Spain | |
| ICO L'Hospitalet - Hospital Duran i Reynals | Barcelona | Spain | |
| Hosp Univ Fund Jimenez Diaz | Madrid | Spain | |
| University College London Hospitals | London | United Kingdom | |
| The Christie NHS Foundation Trust Christie Hospital | Manchester | United Kingdom |
More Janssen Research & Development, LLC trials in South Korea
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT05421663 on ClinicalTrials.gov ↗ ← All trials in South Korea