Assessment of Process and Outcome of Protocol-based Weaning From Mechanical Ventilation in the Medical Patients

Condition(s) studied

Study summary

This is a prospective, single-center, observational study to describe characteristics of weaning process and factors associated with duration of weaning and its outcomes in all consecutive adult (aged 19 years and older) patients receiving mechanical ventilation for at least two calendar days in medical intensive care units since November 2017. Details of the patients' weaning process and spontaneous breathing trial (SBT) in addition to clinical, laboratory, and outcome data will be collected in a specified format on the day of the assessment by respiratory care practitioners.

Eligibility

Primary outcome measure(s)

• Successful weaning — 6 months from MV
  Extubation without death or reintubation within the next 7 days of spontaneous breathing trial or discharge from intensive care unit without invasive mechanical ventilation (MV) within 7 days, whichever comes first for intubated patients and as spontaneous ventilation through tracheostomy without any MV during 7 consecutive days or discharged with spontaneous breathing, whichever comes first for patients with tracheostomy after the first separation attempt
• Weaning outcomes by the Weaning Outcome according to a New Definition (WIND) classification — 6 months from MV
  Group 1 (short weaning), the first attempt result in the termination of the weaning process within 1 day Group 2 (difficult weaning), the weaning process is completed after more than 1 day but in less than 1 week after the first separation attempt Group 3 (prolonged weaning), the weaning process is still not terminated 7 days after the first separation attempt.

Trial sites (1)

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