Peri-treatment of SGLT-2 Inhibitor on Myocardial Infarct Size and Remodeling Index in Patients With Acute Myocardial Infarction and High Risk of Heart Failure Undergoing Percutaneous Coronary Intervention
Condition(s) studied
Investigational drug(s) / intervention(s)
SGLT2 inhibitor: In patients with AMI and high risk of heart failure, 1:1 randomization will be performed to either SGLT2 inhibitor or control group.
Control: In patients with AMI and high risk of heart failure, 1:1 randomization will be performed to either SGLT2 inhibitor or control group.
Study summary
We aimed to identify whether SGLT-2 inhibitor administration before and after coronary intervention is effective in reducing the size of infarction and myocardial remodeling in patients with acute myocardial infarction (AMI) and high risk of heart failure, and its mechanism. For this reason, we compared cardiac magnetic resonance imaging (CMR) parameters and clinical outcomes between the SGLT-2 inhibitor group and the control group to confirm the efficacy and safety of SGLT-2 inhibitors.
Eligibility
Primary outcome measure(s)
- Myocardial infract size (IS) — at 6-month follow-up
IS measured using CMR - ∆Left ventricular end-systolic volume — Between index hospitalization and 6-month follow-up
Difference of left ventricular end-systolic volume measured by CMR
Trial sites (1)
| Facility | City | Region | Status |
|---|---|---|---|
| Samsung Medical Center | Seoul | South Korea | Recruiting |
More Samsung Medical Center trials in South Korea
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT04899479 on ClinicalTrials.gov ↗ ← All trials in South Korea