Efficacy and Safety of Cerebrolysin on Prolonged Disorders of Consciousness
Condition(s) studied
Investigational drug(s) / intervention(s)
Cerebrolysin: 30 ml cerebrolysin + 70 ml normal saline, days 4-17, once/day, intravenously
Control: 100 ml normal saline, days 4-17, once/day, IV
Study summary
Object: To determine the effect of cerebrolysin on prolonged disorders of consciousness caused by hemorrhagic stroke.
Participants: patients with prolonged disorders of consciousness due to severe traumatic brain injury
Intervention: 30 ml cerebrolysin + 70 ml normal saline, days 4-17, once/day, intravenously or 100 ml normal saline, days 4-17, once/day, IV
Comparison: cerebrolysin group versus control group
Outcome: Coma Recovery Scale-revised, FDG-PET signal
Eligibility
Primary outcome measure(s)
- Coma Recovery Scale - revised — 2 days after randomization
Assessing the degree of disorders of consciousness - Coma Recovery Scale - revised — 17 days after randomization
Assessing the degree of disorders of consciousness - Positron Emitting Tomography — 2 days after randomization
Assessing the degree of brain neural network activity - Positron Emitting Tomography — 17 days after randomization
Assessing the degree of brain neural network activity
Trial sites (1)
| Facility | City | Region | Status |
|---|---|---|---|
| Konkuk University Medical Center Research Coordinating Center | Seoul | South Korea | Recruiting |
More Konkuk University Medical Center trials in South Korea
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT04427241 on ClinicalTrials.gov ↗ ← All trials in South Korea