A Study in Participants Previously Enrolled in a Genentech- and/or F. Hoffmann-La Roche Ltd-Sponsored Atezolizumab Study (IMbrella A)
Condition(s) studied
Investigational drug(s) / intervention(s)
Atezolizumab: Atezolizumab will be administered as a monotherapy or atezolizumab with other agent(s) as per parent protocol. Dosing regimen will continue in accordance with the parent study or at equivalent dose (if applicable) and at the same schedule as the parent study, or switch to a fixed atezolizumab dose of 1200 mg every 3 weeks (Q3W).
Bevacizumab: Bevacizumab will be administered as directed per the parent study.
Study summary
This is an open-label, multicenter, non-randomized extension and long-term observational study. Participants receiving atezolizumab monotherapy or atezolizumab combined with other agent(s) or comparator agent(s) in a Genentech or Roche-sponsored study (the parent study) and who continue to receive study treatment at the time of the parent-study closure and do not have access to the study treatment locally are eligible for continued treatment in the extension study. Dosing regimen for a given participant and indication will be the same or equivalent to the respective parent study protocol. Study treatment in the extension study can continue until disease progression or beyond if the patient continues to derive clinical benefit as judged by the investigator and if allowed by the parent study or local prescribing information until death; withdrawal of study consent; unacceptable toxicity; pregnancy; patient non-compliance; or study termination by the Sponsor, whichever occurs first.
Eligibility
Primary outcome measure(s)
- Number of Participants With Continued Access to Atezolizumab-Based Therapy and/or Comparator Agent(s) — Day 1 up to maximum 10 years
Trial sites (170)
| Facility | City | Region | Status |
|---|---|---|---|
| HonorHealth Research Institute ? Bisgrove | Scottsdale | Arizona | |
| Angeles Clinic & Rsch Inst | Los Angeles | California | |
| UCLA | Los Angeles | California | |
| Kaiser Permanente - San Diego (Zion Ave) | San Marcos | California | |
| University Of Colorado | Aurora | Colorado | |
| Rocky Mountain Cancer Ctr - Denver (Williams) | Denver | Colorado | |
| Smilow Cancer Hospital at Yale New Haven | New Haven | Connecticut | |
| Georgetown University Medical Center Lombardi Cancer Center | Washington D.C. | District of Columbia | |
| Florida Cancer Specialists - Fort Myers (Broadway) | Fort Myers | Florida | |
| Hematology Oncology Associates of the Treasure Coast | Port Saint Lucie | Florida | |
| Florida Cancer Specialists. | St. Petersburg | Florida | |
| H. Lee Moffitt Cancer Center and Research Inst. | Tampa | Florida | |
| Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital | Marietta | Georgia | |
| Northwestern University | Chicago | Illinois | |
| Rush University Medical Center | Chicago | Illinois | |
| University Of Chicago Medical Center | Chicago | Illinois | |
| Ingalls Memorial Hospital | Harvey | Illinois | |
| Illinois Cancer Care | Peoria | Illinois | |
| New England Cancer Specialists | Westbrook | Maine | |
| Johns Hopkins Univ Med Center | Baltimore | Maryland | |
| Maryland Oncology Hematology, P.A. | Columbia | Maryland | |
| Massachusetts General Hospital. | Boston | Massachusetts | |
| Beth Israel Medical Center | Boston | Massachusetts | |
| Dana Farber Cancer Inst. | Boston | Massachusetts | |
| Karmanos Cancer Institute | Detroit | Michigan | |
| US oncology research at Minnesota Oncology | Saint Louis Park | Minnesota | |
| Washington University School of Medicine | St Louis | Missouri | |
| Comprehensive Cancer Centers of Nevada - Eastern Avenue | Las Vegas | Nevada | |
| Summit Medical Center | Florham Park | New Jersey | |
| New York Oncology Hematology, P.C. | Albany | New York | |
| Memorial Sloan-Kettering Cancer Center | New York | New York | |
| Carolina BioOncology Institute, PLCC | Huntersville | North Carolina | |
| Cleveland Clinic | Cleveland | Ohio | |
| Oncology Associates of Oregon, P.C | Eugene | Oregon | |
| Northwest Cancer Specialists - Portland (N Broadway) | Portland | Oregon | |
| Penn State Hershey Cancer Institute | Hershey | Pennsylvania | |
| Allegheny Cancer Center | Pittsburgh | Pennsylvania | |
| Sarah Cannon Res Inst | Nashville | Tennessee | |
| Texas Oncology - DFW | Dallas | Texas | |
| Tyler Cancer Center | Tyler | Texas |
+ 130 more sites — see the full list on the official registry below.
More Hoffmann-La Roche trials in South Korea
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT03148418 on ClinicalTrials.gov ↗ ← All trials in South Korea