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Clinical Trials in South Korea / NCT02688894
Recruiting Observational

The Molecular Screening Study for the Umbrella Trial (SUKSES) in Relapsed Small Cell Lung Cancer Patients [SUKSES-S]

NCT02688894 · tracked via the Priya Life Science South Korea tracker
Sponsor
Samsung Medical Center
Phase
Observational
Started
2016-06-10
Last updated
2026-08-12

Condition(s) studied

Small Cell Lung CancersNeuroendocrine Carcinoma

Investigational drug(s) / intervention(s)

No treatment is included in this protocol.

No treatment is included in this protocol.: Tumor tissues (fresh or archival) will be analyzed using NGS-based cancer panel, nanostring CNV, immunohistochemistry and/or FISH. Specific methods of each molecular tests will be defined with standard laboratory manual developed by pathologists.

Study summary

This protocol is a molecular screening protocol only. No drug intervention study will be included in this protocol. Based on the molecular profiling, patients may be eligible for drug intervention study of SUKSES trial.

This procedure can be performed during or after the first-line treatment. DNA will be extracted from the archived or fresh tissue and blood. NGS-based cancer panel and Nanostring CNV will be tested with DNA from tissue and/or blood.

Immunohistochemistry and FISH will be done by pathologists using archived or fresh tissue.

Tumor tissues (fresh or archival) will be analyzed using NGS-based cancer panel, nanostring CNV, immunohistochemistry and/or FISH.

Specific methods of each molecular tests will be defined with standard laboratory manual developed by pathologists.

Eligibility

Sex
ALL
Min age
20 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: 1. Provision of fully informed consent prior to any study specific procedures. 2. Patients must be ≥20 years of age. 3. Histologically or cytologically confirmed Small cell lung cancers 4. ECOG performance status of 0 to 2 5. Patients who are being treated or were treated with platinum-based chemotherapy as a first-line treatment 6. Patients with available archival tissues for molecular analysis or patients who agreed with biopsy for molecular analysis Exclusion Criteria: 1. More than two prior chemotherapy regimen for the treatment of small cell lung cancer 2. Pregnant or nursing women (women of reproductive potential have to agree to use an effective contraceptive method) 3. Patients with second primary cancer, except: adequately treated non-melanoma skin cancer, curatively treated in-situ cancer of the cervix, or other solid tumours curatively treated with no evidence of disease for ≤2 years.

Primary outcome measure(s)

  • Ratio of each molecular subtypes — After registration of this study
    To provide molecular characteristics of SCLC to proceed SUKSES trial

Trial sites (6)

FacilityCityRegionStatus
Gachon University Gil Medical Center Incheon South Korea Completed
Seoul National University Bundang Hospital Seongnam South Korea Completed
Samsung Medical Center Seoul South Korea Recruiting
VHS Medical Center Seoul South Korea Completed
Chungbuk University Hospital Taebuk South Korea Completed
Ulsan University Hospital Ulsan South Korea Completed

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Korean Stroke Cohort for Functioning and Rehabilitation-II Active, not recruiting
Prospective Cohort for Tumor Bed Boost Radiotherapy in HER2 Positive Breast Cancer Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT02688894 on ClinicalTrials.gov ↗ ← All trials in South Korea